Drug profile

The FDA adverse-event record for Desoxycortone

754 FDA reports name Desoxycortone, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#224 of 2,679
by report volume (all drugs)
754
adverse-event reports
8.0%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Desoxycortone ranks #224 of 2679 by total reports (754) and #642 of 1130 by death-coded share (8.0%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#224
This drug, reports of 2679
#642
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Desoxycortone has 754 reports now versus 743 in that prior snapshot: 11 more (1.5%).

Report change
+11
Death-coded reports
+0
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Desoxycortone changes

Signature read: 754 reports place Desoxycortone in the upper third of FDA AER volume (#224 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
754
Total Reports
60
Deaths Reported
8.0%
Death-coded share of reports

Active Ingredients

Desoxycortone

Administration Routes

IntramuscularParenteralUnknownSubcutaneousOralIntravenousOtherCutaneousRespiratory (Inhalation)Topical

Species Affected

Dog 651
Unknown 96
Human 5
Cat 2

Most Affected Breeds

Unknown 101
Retriever - Labrador 73
Dog (unknown) 73
Crossbred Canine/dog 27
Poodle - Standard 25
Pit Bull 25
Terrier - West Highland White 22
Retriever - Golden 22
Chihuahua 20
Poodle (unspecified) 19

Most Reported Reactions

Lack of efficacy - NOS 109
Vomiting 92
Lethargy (see also Central nervous system depression in 'Neurological') 80
Other abnormal test result NOS 74
Polydipsia 60
Polyuria 60
Weight gain 52
Diarrhoea 49
Incorrect route of drug administration 49
Weight loss 44
Product problem 44
Not eating 38

Outcome Breakdown

Outcome Unknown
249 (37.8%)
Ongoing
220 (33.4%)
Recovered/Normal
111 (16.9%)
Died
33 (5.0%)
Euthanized
27 (4.1%)
Recovered with Sequela
18 (2.7%)

Desoxycortone: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Desoxycortone, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar report volume

Nearest other drugs by FDA report count (754 here).

Similar death-coded share

Nearest other drugs by death-coded share (8.0% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Desoxycortone (#224 of 2,679 by report volume); death-coded 8.0%. PlainBreed drug row · report volume stamp 754 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →