Drug profile

The FDA adverse-event record for Depo-Medrol

13 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Depo-Medrol. See the species affected, top reactions, and outcomes below.

13
adverse-event reports
23.1%
death-coded share
Cat
most-reported species
2
Death - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
13
Total Reports
3
Deaths Reported
23.1%
Death Rate

Active Ingredients

Depo-Medrol

Administration Routes

UnknownSubcutaneousIntramuscular

Species Affected

Cat 10
Dog 3

Most Affected Breeds

Domestic Shorthair 8
Spitz - German Pomeranian 1
Shih Tzu 1
Shepherd Dog - German 1
Rex - Devon 1
British Blue 1

Most Reported Reactions

Death 2
Weight loss 2
Hypersalivation 2
Pulmonary oedema 2
Seizure NOS 2
Third eyelid protrusion 2
Anisocoria 2
Ataxia 2
Decreased appetite 2
Non-regenerative anaemia 1
Splenomegaly 1
Pale mucous membrane 1

Outcome Breakdown

Ongoing
4 (30.8%)
Outcome Unknown
3 (23.1%)
Recovered/Normal
3 (23.1%)
Died
2 (15.4%)
Euthanized
1 (7.7%)

Depo-Medrol Adverse Event Insights

13 reports name Depo-Medrol; 3 recorded a death outcome (23.1% of reported events, not a population-level mortality rate). Active ingredient: Depo-Medrol. Administration routes: Unknown, Subcutaneous, Intramuscular.

By species: Cat (10 reports), Dog (3 reports). By breed: Domestic Shorthair (8), Spitz - German Pomeranian (1), Shih Tzu (1).

Leading clinical signs: Death (2), Weight loss (2), Hypersalivation (2), Pulmonary oedema (2). Outcome, 13 coded reports: Ongoing leads at 30.8%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.