Drug profile

The FDA adverse-event record for Dapp+L4 Vaccine

32 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Dapp+L4 Vaccine. See the species affected, top reactions, and outcomes below.

32
adverse-event reports
15.6%
death-coded share
Dog
most-reported species
10
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
32
Total Reports
5
Deaths Reported
15.6%
Death Rate

Active Ingredients

Dapp+L4 Vaccine

Administration Routes

UnknownSubcutaneous

Species Affected

Dog 32

Most Affected Breeds

Terrier - Bull - American Pit 5
Bulldog - French 2
Dachshund - Miniature 2
Terrier - Yorkshire 2
Shepherd Dog - German 2
Beagle 1
Corgi (unspecified) 1
Shepherd Dog - Australian 1
Boxer (German Boxer) 1
Spaniel (unspecified) 1

Most Reported Reactions

Vomiting 10
Anaphylaxis 9
Facial swelling (see also Skin) 6
Hives (see also Skin) 6
Pale mucous membrane 4
Decreased appetite 4
Diarrhoea 3
Lethargy (see also Central nervous system depression in 'Neurological') 3
Death by euthanasia 3
Hypersensitivity reaction 3
Lethargy (see also Central nervous system depression in Neurological) 3
Seizure NOS 2

Outcome Breakdown

Ongoing
14 (43.8%)
Recovered/Normal
13 (40.6%)
Euthanized
3 (9.4%)
Died
2 (6.3%)

Dapp+L4 Vaccine Adverse Event Insights

32 reports name Dapp+L4 Vaccine; 5 recorded a death outcome (15.6% of reported events, not a population-level mortality rate). Active ingredient: Dapp+L4 Vaccine. Administration routes: Unknown, Subcutaneous.

By species: Dog (32 reports). By breed: Terrier - Bull - American Pit (5), Bulldog - French (2), Dachshund - Miniature (2).

Leading clinical signs: Vomiting (10), Anaphylaxis (9), Facial swelling (see also Skin) (6), Hives (see also Skin) (6). Outcome, 32 coded reports: Ongoing leads at 43.8%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.