Drug profile

The FDA adverse-event record for Dappl4

11 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Dappl4. See the species affected, top reactions, and outcomes below.

11
adverse-event reports
9.1%
death-coded share
Dog
most-reported species
4
Facial swelling (see also Skin) - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
11
Total Reports
1
Deaths Reported
9.1%
Death Rate

Active Ingredients

Dappl4

Administration Routes

SubcutaneousUnknown

Species Affected

Dog 11

Most Affected Breeds

Retriever - Golden 1
Rottweiler 1
Akita 1
Terrier - Bull - American Pit 1
Mastiff 1
Hound (unspecified) 1
Weimaraner 1
Chihuahua 1
Crossbred Canine/dog 1
Schnauzer (unspecified) 1

Most Reported Reactions

Facial swelling (see also Skin) 4
Emesis 4
Vomiting 3
Hives (see also Skin) 3
Diarrhoea 2
Facial swelling (see also 'Skin') 1
Allergic reaction 1
Lethargy (see also Central nervous system depression in 'Neurological') 1
Lateral recumbency 1
Seizure NOS 1
Fixed pupil 1
Death 1

Outcome Breakdown

Recovered/Normal
6 (54.5%)
Ongoing
3 (27.3%)
Died
1 (9.1%)
Outcome Unknown
1 (9.1%)

Dappl4 Adverse Event Insights

11 reports name Dappl4; 1 recorded a death outcome (9.1% of reported events, not a population-level mortality rate). Active ingredient: Dappl4. Administration routes: Subcutaneous, Unknown.

By species: Dog (11 reports). By breed: Retriever - Golden (1), Rottweiler (1), Akita (1).

Leading clinical signs: Facial swelling (see also Skin) (4), Emesis (4), Vomiting (3), Hives (see also Skin) (3). Outcome, 11 coded reports: Recovered/Normal leads at 54.5%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.