Drug profile

The FDA adverse-event record for Dapp Vaccine

228 FDA reports name Dapp Vaccine, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#511 of 2,679
by report volume (all drugs)
228
adverse-event reports
14.9%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Dapp Vaccine ranks #511 of 2679 by total reports (228) and #368 of 1130 by death-coded share (14.9%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#511
This drug, reports of 2679
#368
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Dapp Vaccine has 228 reports now versus 211 in that prior snapshot: 17 more (8.1%).

Report change
+17
Death-coded reports
+0
Death-coded share
−1.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Dapp Vaccine changes

Signature read: death-coded report count at 34 is the most distinctive stamp on Dapp Vaccine's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
228
Total Reports
34
Deaths Reported
14.9%
Death-coded share of reports

Active Ingredients

Dapp Vaccine

Administration Routes

UnknownSubcutaneousOral

Species Affected

Dog 228

Most Affected Breeds

Retriever - Labrador 25
Terrier - Yorkshire 21
Chihuahua 19
Retriever - Golden 14
Terrier - Bull - American Pit 12
Bulldog - French 7
Crossbred Canine/dog 6
Shepherd Dog - German 6
Siberian Husky 5
Dachshund (unspecified) 5

Most Reported Reactions

Vomiting 64
Lethargy (see also Central nervous system depression in Neurological) 41
Facial swelling (see also Skin) 35
Diarrhoea 34
Anaphylaxis 26
Seizure NOS 23
Hives (see also Skin) 21
Emesis (multiple) 21
Death by euthanasia 17
Fever 17
Death 16
Hypersensitivity reaction 15

Outcome Breakdown

Ongoing
112 (49.1%)
Recovered/Normal
70 (30.7%)
Died
17 (7.5%)
Euthanized
17 (7.5%)
Outcome Unknown
12 (5.3%)

Dapp Vaccine: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Dapp Vaccine, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (14.9% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Dapp Vaccine (#511 of 2,679 by report volume); death-coded 14.9%. PlainBreed drug row · death-coded report count stamp 34 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →