Drug profile

The FDA adverse-event record for Danofloxacin Mesylate

53 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Danofloxacin Mesylate. Species, reactions, and outcomes follow.

#1080 of 2,679
by report volume (all drugs)
53
adverse-event reports
60.4%
death-coded share
Cattle
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Danofloxacin Mesylate ranks #1077 of 2679 by total reports (53) and #42 of 1130 by death-coded share (60.4%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1077
This drug, reports of 2679
#42
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Danofloxacin Mesylate has 53 reports now versus 52 in that prior snapshot: 1 more (1.9%).

Report change
+1
Death-coded reports
+1
Death-coded share
+0.8 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Danofloxacin Mesylate changes

Signature read: Danofloxacin Mesylate's 60.4% death-coded share is among the highest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
53
Total Reports
32
Deaths Reported
60.4%
Death-coded share of reports

Active Ingredients

Danofloxacin Mesylate

Administration Routes

SubcutaneousUnknownTopicalIntramuscularIntravenousOther

Species Affected

Cattle 42
Unknown 8
Human 2
Dog 1

Most Affected Breeds

Cattle (other) 21
Mixed (Cattle) 17
Unknown 10
Aberdeen Angus 2
Cattle (unknown) 1
Crossbred Bovine/Cattle 1
Black Mouth Cur 1

Most Reported Reactions

Death 25
Lack of efficacy (bacteria) - NOS 13
Lack of efficacy - NOS 13
Necropsy performed 9
Bronchopneumonia 6
Found dead 5
Unclassifiable adverse event 4
Pneumonia 4
Lung oedema 4
Death by euthanasia 3
Uncoded sign 3
Residues in meat/offal 3

Outcome Breakdown

Died
31 (43.1%)
Outcome Unknown
24 (33.3%)
Recovered/Normal
7 (9.7%)
Ongoing
4 (5.6%)
Recovered with Sequela
3 (4.2%)
Euthanized
3 (4.2%)

Danofloxacin Mesylate: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Nationwide drugs with similar profiles

Two openFDA-derived peer sets for Danofloxacin Mesylate, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

  • Compare Danofloxacin Mesylate's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Danofloxacin Mesylate (#1080 of 2,679 by report volume); death-coded 60.4%. PlainBreed drug row · death-coded share stamp 60.4% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →