Drug profile

The FDA adverse-event record for Credelio

60 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Credelio. Species, reactions, and outcomes follow.

#1012 of 2,679
by report volume (all drugs)
60
adverse-event reports
6.7%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Credelio ranks #1012 of 2679 by total reports (60) and #710 of 1130 by death-coded share (6.7%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1012
This drug, reports of 2679
#710
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Credelio has 60 reports now versus 58 in that prior snapshot: 2 more (3.4%).

Report change
+2
Death-coded reports
+0
Death-coded share
−0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Credelio changes

Signature read: death-coded share at 6.7% is the most distinctive stamp on Credelio's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
60
Total Reports
4
Deaths Reported
6.7%
Death-coded share of reports

Active Ingredients

Credelio

Administration Routes

OralUnknown

Species Affected

Dog 56
Cat 4

Most Affected Breeds

Shepherd Dog - German 6
Retriever - Labrador 6
Shih Tzu 4
Crossbred Canine/dog 4
Terrier - Bull - American Pit 3
Spaniel - King Charles Cavalier 3
Domestic Shorthair 3
Beagle 3
Retriever - Golden 3
Dog (unknown) 2

Most Reported Reactions

Lack of efficacy (bacteria) - Borrelia 6
Seizure NOS 6
Lethargy (see also Central nervous system depression in Neurological) 6
Vomiting 5
Urinary tract infection 4
Death by euthanasia 4
Urinary incontinence 4
Polydipsia 3
Polyuria 3
Lack of efficacy (endoparasite) - heartworm 3
Weight loss 3
Leucopenia NOS 3

Outcome Breakdown

Ongoing
37 (61.7%)
Outcome Unknown
12 (20.0%)
Recovered/Normal
7 (11.7%)
Euthanized
4 (6.7%)

Credelio Adverse Event Insights

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Nationwide drugs with similar profiles

Two openFDA-derived peer sets for Credelio, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar report volume

Nearest other drugs by FDA report count (60 here).

Similar death-coded share

Nearest other drugs by death-coded share (6.7% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Credelio (#1012 of 2,679 by report volume); death-coded 6.7%. PlainBreed drug row · death-coded share stamp 6.7% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →