Drug profile

The FDA adverse-event record for Credelio

57 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Credelio. See the species affected, top reactions, and outcomes below.

57
adverse-event reports
7.0%
death-coded share
Dog
most-reported species
6
Lethargy (see also Central nervous system depression in Neurological) - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
57
Total Reports
4
Deaths Reported
7.0%
Death Rate

Active Ingredients

Credelio

Administration Routes

OralUnknown

Species Affected

Dog 53
Cat 4

Most Affected Breeds

Shepherd Dog - German 6
Retriever - Labrador 6
Shih Tzu 4
Crossbred Canine/dog 4
Terrier - Bull - American Pit 3
Spaniel - King Charles Cavalier 3
Domestic Shorthair 3
Beagle 3
Retriever - Golden 2
Dog (unknown) 2

Most Reported Reactions

Lethargy (see also Central nervous system depression in Neurological) 6
Lack of efficacy (bacteria) - Borrelia 5
Seizure NOS 5
Vomiting 5
Urinary tract infection 4
Death by euthanasia 4
Urinary incontinence 4
Polydipsia 3
Polyuria 3
Weight loss 3
Leucopenia NOS 3
Lack of efficacy (bacteria) - NOS 3

Outcome Breakdown

Ongoing
35 (61.4%)
Outcome Unknown
11 (19.3%)
Recovered/Normal
7 (12.3%)
Euthanized
4 (7.0%)

Credelio Adverse Event Insights

57 reports name Credelio; 4 recorded a death outcome (7.0% of reported events, not a population-level mortality rate). Active ingredient: Credelio. Administration routes: Oral, Unknown.

By species: Dog (53 reports), Cat (4 reports). By breed: Shepherd Dog - German (6), Retriever - Labrador (6), Shih Tzu (4).

Leading clinical signs: Lethargy (see also Central nervous system depression in Neurological) (6), Lack of efficacy (bacteria) - Borrelia (5), Seizure NOS (5), Vomiting (5). Outcome, 57 coded reports: Ongoing leads at 61.4%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.