Drug profile

The FDA adverse-event record for Copper Naphthenate

183 FDA reports name Copper Naphthenate, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#558 of 2,679
by report volume (all drugs)
183
adverse-event reports
0.5%
death-coded share
Unknown
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Copper Naphthenate ranks #558 of 2679 by total reports (183) and #1094 of 1130 by death-coded share (0.5%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#558
This drug, reports of 2679
#1094
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Copper Naphthenate has 183 reports now versus 183 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Copper Naphthenate changes

Signature read: Copper Naphthenate's 0.5% death-coded share is among the lowest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
183
Total Reports
1
Deaths Reported
0.5%
Death-coded share of reports

Active Ingredients

Copper Naphthenate

Administration Routes

UnknownTopicalOralOphthalmicOtherRespiratory (Inhalation)NasalIntradermal

Species Affected

Unknown 98
Human 44
Horse 15
Dog 14
Cat 5
Goat 4
Sheep 2
Other Deer 1

Most Affected Breeds

Unknown 145
Quarter Horse 5
Paint 4
Domestic (unspecified) 4
Retriever - Labrador 2
Goat (unknown) 2
Retriever - Golden 2
Sheep (unknown) 2
Miniature 2
Horse (unknown) 2

Most Reported Reactions

Accidental exposure 50
Vials, Leaking 49
Unclassifiable adverse event 21
No sign 20
Seal, Abnormal 15
Containers, Leaking 15
Caps, Abnormal 13
Containers, Damaged 10
Eye irritation 9
Bottles, Damaged 8
Closure, Abnormal 8
Nausea 6

Outcome Breakdown

Outcome Unknown
35 (71.4%)
Recovered/Normal
11 (22.4%)
Ongoing
2 (4.1%)
Died
1 (2.0%)

Copper Naphthenate: low death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Copper Naphthenate, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Copper Naphthenate (#558 of 2,679 by report volume); death-coded 0.5%. PlainBreed drug row · death-coded share stamp 0.5% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →