Clostridium Chauvoei, F, Kb; Clostridium Novyi, 8296, Kb; Clostridium Perfringen

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36 adverse event reports submitted to the FDA

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
36
Total Reports
28
Deaths Reported
7780.0%
Death Rate

Active Ingredients

Clostridium Chauvoei, F, Kb; Clostridium Novyi, 8296, Kb; Clostridium Perfringen

Administration Routes

SubcutaneousUnknownIntramuscular

Species Affected

Cattle 35
Unknown 1

Most Affected Breeds

Cattle (other) 27
Crossbred Bovine/Cattle 5
Aberdeen Angus 1
Cattle (unspecified) 1
Cattle (unknown) 1
Unknown 1

Most Reported Reactions

Lack of efficacy (bacteria) - NOS 30
Death 20
Lack of efficacy - NOS 8
CULTURE/TITER DATA ABNORMAL 7
DEATH-TREATMENT FAILURE 6
PR-LUNG(S), LESION(S) 5
Death by euthanasia 2
Injection site lump 2
Copper deficiency signs 1
Illness NOS 1
Temporary blindness 1
Aggression 1

Outcome Breakdown

Died
28 (43.1%)
Outcome Unknown
22 (33.8%)
Ongoing
7 (10.8%)
Recovered/Normal
5 (7.7%)
Recovered with Sequela
2 (3.1%)
Euthanized
1 (1.5%)

Data Summary

Metric Value
Total adverse event reports 36
Reports involving death 28
Case-fatality rate (reported events) 7780.0%
Distinct species in reports 2
Distinct breeds in reports 6
Distinct reactions reported 18
Active ingredients on file 1

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER). Counts reflect voluntary reports only.

Clostridium Chauvoei, F, Kb; Clostridium Novyi, 8296, Kb; Clostridium Perfringen Adverse Event Insights

The FDA Center for Veterinary Medicine database currently holds 36 adverse event reports referencing Clostridium Chauvoei, F, Kb; Clostridium Novyi, 8296, Kb; Clostridium Perfringen, including 28 reports in which the animal died — a 7780.0% case-fatality figure among reported events only, not a population-level mortality rate. Active ingredient on file: Clostridium Chauvoei, F, Kb; Clostridium Novyi, 8296, Kb; Clostridium Perfringen. Reported administration routes include Subcutaneous, Unknown, Intramuscular. These numbers reflect voluntary submissions from pet owners, veterinarians, and manufacturers and therefore under-represent mild events and over-represent severe ones — a pattern the FDA has documented repeatedly for pharmacovigilance datasets.

The species most frequently named in Clostridium Chauvoei, F, Kb; Clostridium Novyi, 8296, Kb; Clostridium Perfringen reports are Cattle (35 reports), Unknown (1 reports), with Cattle accounting for the largest share. Within those species, Cattle (other) (27), Crossbred Bovine/Cattle (5), Aberdeen Angus (1) appear most often — though breed popularity and ownership density shape these counts as much as any drug-specific sensitivity. This distribution matters because the same active ingredient can behave very differently across body sizes, ages, and species physiology.

The most commonly reported clinical signs associated with Clostridium Chauvoei, F, Kb; Clostridium Novyi, 8296, Kb; Clostridium Perfringen are Lack of efficacy (bacteria) - NOS (30), Death (20), Lack of efficacy - NOS (8), CULTURE/TITER DATA ABNORMAL (7). Of the 65 reports with a coded outcome, Died is the leading category at 43.1%. Because FDA adverse event data describes correlation rather than causation, these figures are best used to frame informed questions with a veterinarian and to compare reporting patterns across related products — not as a standalone safety verdict on Clostridium Chauvoei, F, Kb; Clostridium Novyi, 8296, Kb; Clostridium Perfringen.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial