Clostridium Chauvoei + Clostridium Novyi + Clostridium Perfringens Type C + Clostridium Perfringens Type D Bacterin Toxoid + Clostridium Septicum + Clostridium Sordellii

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31 adverse event reports submitted to the FDA

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
31
Total Reports
24
Deaths Reported
7740.0%
Death Rate

Active Ingredients

Clostridium ChauvoeiClostridium NovyiClostridium Perfringens Type CClostridium Perfringens Type D Bacterin ToxoidClostridium SepticumClostridium Sordellii

Administration Routes

UnknownSubcutaneous

Species Affected

Cattle 31

Most Affected Breeds

Cattle (other) 18
Aberdeen Angus 7
Cattle (unknown) 4
Charolais 2

Most Reported Reactions

Death 23
Lack of efficacy - NOS 11
Lack of efficacy (bacteria) - NOS 3
Respiratory signs 2
Other abnormal test result NOS 2
CULTURE/TITER DATA ABNORMAL 2
Necropsy performed 2
Death by euthanasia 2
Injection site granuloma 1
Injection site infection 1
NT - fibrinous (broncho) pneumonia/fibrinous pleuropneumonia 1
INEFFECTIVE, WORMS 1

Outcome Breakdown

Died
24 (51.1%)
Outcome Unknown
10 (21.3%)
Recovered/Normal
7 (14.9%)
Ongoing
4 (8.5%)
Recovered with Sequela
1 (2.1%)
Euthanized
1 (2.1%)

Data Summary

Metric Value
Total adverse event reports 31
Reports involving death 24
Case-fatality rate (reported events) 7740.0%
Distinct species in reports 1
Distinct breeds in reports 4
Distinct reactions reported 20
Active ingredients on file 6

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER). Counts reflect voluntary reports only.

Clostridium Chauvoei + Clostridium Novyi + Clostridium Perfringens Type C + Clostridium Perfringens Type D Bacterin Toxoid + Clostridium Septicum + Clostridium Sordellii Adverse Event Insights

The FDA Center for Veterinary Medicine database currently holds 31 adverse event reports referencing Clostridium Chauvoei + Clostridium Novyi + Clostridium Perfringens Type C + Clostridium Perfringens Type D Bacterin Toxoid + Clostridium Septicum + Clostridium Sordellii, including 24 reports in which the animal died — a 7740.0% case-fatality figure among reported events only, not a population-level mortality rate. Active ingredients on file: Clostridium Chauvoei, Clostridium Novyi, Clostridium Perfringens Type C, Clostridium Perfringens Type D Bacterin Toxoid, Clostridium Septicum. Reported administration routes include Unknown, Subcutaneous. These numbers reflect voluntary submissions from pet owners, veterinarians, and manufacturers and therefore under-represent mild events and over-represent severe ones — a pattern the FDA has documented repeatedly for pharmacovigilance datasets.

The species most frequently named in Clostridium Chauvoei + Clostridium Novyi + Clostridium Perfringens Type C + Clostridium Perfringens Type D Bacterin Toxoid + Clostridium Septicum + Clostridium Sordellii reports are Cattle (31 reports), with Cattle accounting for the largest share. Within those species, Cattle (other) (18), Aberdeen Angus (7), Cattle (unknown) (4) appear most often — though breed popularity and ownership density shape these counts as much as any drug-specific sensitivity. This distribution matters because the same active ingredient can behave very differently across body sizes, ages, and species physiology.

The most commonly reported clinical signs associated with Clostridium Chauvoei + Clostridium Novyi + Clostridium Perfringens Type C + Clostridium Perfringens Type D Bacterin Toxoid + Clostridium Septicum + Clostridium Sordellii are Death (23), Lack of efficacy - NOS (11), Lack of efficacy (bacteria) - NOS (3), Respiratory signs (2). Of the 47 reports with a coded outcome, Died is the leading category at 51.1%. Because FDA adverse event data describes correlation rather than causation, these figures are best used to frame informed questions with a veterinarian and to compare reporting patterns across related products — not as a standalone safety verdict on Clostridium Chauvoei + Clostridium Novyi + Clostridium Perfringens Type C + Clostridium Perfringens Type D Bacterin Toxoid + Clostridium Septicum + Clostridium Sordellii.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

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Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial