Drug profile

The FDA adverse-event record for Clostridium Chauvoei Bacterin Toxoid + Clostridium Novyi Bacterin Toxoid + Clostridium Perfringens Type C Bacterin Toxoid + Clostridium Perfringens Type D Bacterin Toxoid + Clostridium Septicum Bacterin Toxoid + Clostridium Sordellii Bacterin Toxoid

36 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Clostridium Chauvoei Bacterin Toxoid + Clostridium Novyi Bacterin Toxoid + Clostridium Perfringens Type C Bacterin Toxoid + Clostridium Perfringens Type D Bacterin Toxoid + Clostridium Septicum Bacterin Toxoid + Clostridium Sordellii Bacterin Toxoid. Species, reactions, and outcomes follow.

#1314 of 2,679
by report volume (all drugs)
36
adverse-event reports
86.1%
death-coded share
Cattle
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Clostridium Chauvoei Bacterin Toxoid + Clostridium Novyi Bacterin Toxoid + Clostridium Perfringens Type C Bacterin Toxoid + Clostridium Perfringens Type D Bacterin Toxoid + Clostridium Septicum Bacterin Toxoid + Clostridium Sordellii Bacterin Toxoid ranks #1311 of 2679 by total reports (36). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1311
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Clostridium Chauvoei Bacterin Toxoid + Clostridium Novyi Bacterin Toxoid + Clostridium Perfringens Type C Bacterin Toxoid + Clostridium Perfringens Type D Bacterin Toxoid + Clostridium Septicum Bacterin Toxoid + Clostridium Sordellii Bacterin Toxoid has 36 reports now versus 35 in that prior snapshot: 1 more (2.9%).

Report change
+1
Death-coded reports
+1
Death-coded share
+0.4 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Clostridium Chauvoei Bacterin Toxoid + Clostridium Novyi Bacterin Toxoid + Clostridium Perfringens Type C Bacterin Toxoid + Clostridium Perfringens Type D Bacterin Toxoid + Clostridium Septicum Bacterin Toxoid + Clostridium Sordellii Bacterin Toxoid changes

Signature read: Clostridium Chauvoei Bacterin Toxoid + Clostridium Novyi Bacterin Toxoid + Clostridium Perfringens Type C Bacterin Toxoid + Clostridium Perfringens Type D Bacterin Toxoid + Clostridium Septicum Bacterin Toxoid + Clostridium Sordellii Bacterin Toxoid's 86.1% death-coded share is among the highest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
36
Total Reports
31
Deaths Reported
86.1%
Death-coded share of reports

Active Ingredients

Clostridium Chauvoei Bacterin ToxoidClostridium Novyi Bacterin ToxoidClostridium Perfringens Type C Bacterin ToxoidClostridium Perfringens Type D Bacterin ToxoidClostridium Septicum Bacterin ToxoidClostridium Sordellii Bacterin Toxoid

Administration Routes

UnknownSubcutaneousIntramuscular

Species Affected

Cattle 36

Most Affected Breeds

Cattle (other) 19
Crossbred Bovine/Cattle 7
Cattle (unknown) 4
Aberdeen Angus 3
Holstein-Friesian also known as Holstein 2
Charolais 1

Most Reported Reactions

Death 27
Lack of efficacy - NOS 22
Necropsy performed 5
Depression 3
Anorexia 3
Death by euthanasia 3
Recumbency 2
Bloody diarrhoea 2
Fever 2
Lack of efficacy (bacteria) - NOS 2
NT - necrohemorrhagic enteritis 1
NT - ulcerative colitis 1

Outcome Breakdown

Died
29 (50.0%)
Outcome Unknown
12 (20.7%)
Recovered/Normal
7 (12.1%)
Ongoing
6 (10.3%)
Recovered with Sequela
2 (3.4%)
Euthanized
2 (3.4%)

Clostridium Chauvoei Bacterin Toxoid + Clostridium Novyi Bacterin Toxoid + Clostridium Perfringens Type C Bacterin Toxoid + Clostridium Perfringens Type D Bacterin Toxoid + Clostridium Septicum Bacterin Toxoid + Clostridium Sordellii Bacterin Toxoid: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Clostridium Chauvoei Bacterin Toxoid + Clostridium Novyi Bacterin Toxoid + Clostridium Perfringens Type C Bacterin Toxoid + Clostridium Perfringens Type D Bacterin Toxoid + Clostridium Septicum Bacterin Toxoid + Clostridium Sordellii Bacterin Toxoid (#1314 of 2,679 by report volume); death-coded 86.1%. PlainBreed drug row · death-coded share stamp 86.1% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →