Drug profile

The FDA adverse-event record for Clos Perf Cd/Clos Oth*4,Tet Kb

17 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Clos Perf Cd/Clos Oth*4,Tet Kb. See the species affected, top reactions, and outcomes below.

17
adverse-event reports
94.1%
death-coded share
Cattle
most-reported species
15
Death - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
17
Total Reports
16
Deaths Reported
94.1%
Death Rate

Active Ingredients

Clos Perf Cd/Clos Oth*4,Tet Kb

Administration Routes

SubcutaneousUnknownIntramuscular

Species Affected

Cattle 17

Most Affected Breeds

Cattle (other) 9
Holstein-Friesian also known as Holstein 4
Aberdeen Angus 1
Simmental 1
Cattle (unknown) 1
Cattle (unspecified) 1

Most Reported Reactions

Death 15
Lack of efficacy - NOS 7
Lack of efficacy (bacteria) - NOS 3
Droopy ear 2
Bloated 2
Necropsy performed 2
Death by euthanasia 2
Lameness 2
Injection site swelling 1
Injection site pain 1
Lethargy (see also Central nervous system depression in 'Neurological') 1
INEFFECTIVE, ANTIINFLAMMATORY 1

Outcome Breakdown

Died
16 (35.6%)
Ongoing
13 (28.9%)
Recovered/Normal
13 (28.9%)
Euthanized
2 (4.4%)
Outcome Unknown
1 (2.2%)

Clos Perf Cd/Clos Oth*4,Tet Kb Adverse Event Insights

17 reports name Clos Perf Cd/Clos Oth*4,Tet Kb; 16 recorded a death outcome (94.1% of reported events, not a population-level mortality rate). Active ingredient: Clos Perf Cd/Clos Oth*4,Tet Kb. Administration routes: Subcutaneous, Unknown, Intramuscular.

By species: Cattle (17 reports). By breed: Cattle (other) (9), Holstein-Friesian also known as Holstein (4), Aberdeen Angus (1).

Leading clinical signs: Death (15), Lack of efficacy - NOS (7), Lack of efficacy (bacteria) - NOS (3), Droopy ear (2). Outcome, 45 coded reports: Died leads at 35.6%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.