Drug profile

The FDA adverse-event record for Cloprostenol 263 Inj Cattle

151 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Cloprostenol 263 Inj Cattle. See the species affected, top reactions, and outcomes below.

151
adverse-event reports
15.9%
death-coded share
Cattle
most-reported species
25
Lack of efficacy - NOS - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
151
Total Reports
24
Deaths Reported
15.9%
Death Rate

Active Ingredients

Cloprostenol 263 Inj Cattle

Administration Routes

UnknownIntramuscularTopicalSubcutaneousParenteralIntravenousOralRespiratory (Inhalation)

Species Affected

Cattle 74
Unknown 44
Human 17
Horse 8
Sheep 3
Pig 1
Goat 1
Donkey 1
Other 1
Other Equids 1

Most Affected Breeds

Unknown 62
Cattle (other) 33
Holstein-Friesian also known as Holstein 12
Aberdeen Angus 11
Cattle (unspecified) 6
Crossbred Bovine/Cattle 6
Horse (unknown) 4
Red Angus 2
Mixed (Horse) 2
Commercial hybrid 1

Most Reported Reactions

Lack of efficacy - NOS 25
INEFFECTIVE, ESTRUS SYNCHRONIZ 23
Death 23
INEFFECTIVE, ESTRUS INDUCTION 16
Closure, Abnormal 16
Hyperextension 11
Uncoded sign 10
Accidental exposure 10
Product problem 9
Seal, Abnormal 8
Caps, Abnormal 8
Stopper, abnormal 8

Outcome Breakdown

Outcome Unknown
58 (43.9%)
Recovered/Normal
32 (24.2%)
Died
24 (18.2%)
Ongoing
18 (13.6%)

Cloprostenol 263 Inj Cattle Adverse Event Insights

151 reports name Cloprostenol 263 Inj Cattle; 24 recorded a death outcome (15.9% of reported events, not a population-level mortality rate). Active ingredient: Cloprostenol 263 Inj Cattle. Administration routes: Unknown, Intramuscular, Topical, Subcutaneous.

By species: Cattle (74 reports), Unknown (44 reports), Human (17 reports). By breed: Unknown (62), Cattle (other) (33), Holstein-Friesian also known as Holstein (12).

Leading clinical signs: Lack of efficacy - NOS (25), INEFFECTIVE, ESTRUS SYNCHRONIZ (23), Death (23), INEFFECTIVE, ESTRUS INDUCTION (16). Outcome, 132 coded reports: Outcome Unknown leads at 43.9%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.