Drug profile

The FDA adverse-event record for Cloprostenol 263 Inj Cattle

154 FDA reports name Cloprostenol 263 Inj Cattle, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#619 of 2,679
by report volume (all drugs)
154
adverse-event reports
16.9%
death-coded share
Cattle
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Cloprostenol 263 Inj Cattle ranks #619 of 2679 by total reports (154) and #311 of 1130 by death-coded share (16.9%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#619
This drug, reports of 2679
#311
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Cloprostenol 263 Inj Cattle has 154 reports now versus 153 in that prior snapshot: 1 more (0.7%).

Report change
+1
Death-coded reports
+0
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Cloprostenol 263 Inj Cattle changes

Signature read: death-coded report count at 26 is the most distinctive stamp on Cloprostenol 263 Inj Cattle's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
154
Total Reports
26
Deaths Reported
16.9%
Death-coded share of reports

Active Ingredients

Cloprostenol 263 Inj Cattle

Administration Routes

UnknownIntramuscularTopicalSubcutaneousParenteralIntravenousOralRespiratory (Inhalation)

Species Affected

Cattle 76
Unknown 44
Human 17
Horse 9
Sheep 3
Pig 1
Goat 1
Donkey 1
Other 1
Other Equids 1

Most Affected Breeds

Unknown 62
Cattle (other) 33
Holstein-Friesian also known as Holstein 13
Aberdeen Angus 11
Crossbred Bovine/Cattle 7
Cattle (unspecified) 6
Horse (unknown) 4
Red Angus 2
Mixed (Horse) 2
Quarter Horse 2

Most Reported Reactions

Lack of efficacy - NOS 25
Death 25
INEFFECTIVE, ESTRUS SYNCHRONIZ 23
INEFFECTIVE, ESTRUS INDUCTION 16
Closure, Abnormal 16
Hyperextension 11
Uncoded sign 10
Accidental exposure 10
Product problem 9
Caps, Abnormal 8
Seal, Abnormal 8
Stopper, abnormal 8

Outcome Breakdown

Outcome Unknown
58 (42.6%)
Recovered/Normal
33 (24.3%)
Died
26 (19.1%)
Ongoing
19 (14.0%)

Cloprostenol 263 Inj Cattle: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Cloprostenol 263 Inj Cattle, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

  • Compare Cloprostenol 263 Inj Cattle's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Cloprostenol 263 Inj Cattle (#619 of 2,679 by report volume); death-coded 16.9%. PlainBreed drug row · death-coded report count stamp 26 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →