Drug profile

The FDA adverse-event record for Clonidine Hcl

20 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Clonidine Hcl. See the species affected, top reactions, and outcomes below.

20
adverse-event reports
15.0%
death-coded share
Dog
most-reported species
6
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
20
Total Reports
3
Deaths Reported
15.0%
Death Rate

Active Ingredients

Clonidine Hcl

Administration Routes

OralUnknown

Species Affected

Dog 18
Human 2

Most Affected Breeds

Shepherd Dog - German 4
Terrier - Bull - American Pit 3
Unknown 2
Terrier - Fox Wire 2
Spaniel - King Charles Cavalier 1
Rottweiler 1
Setter - English 1
Retriever - Labrador 1
Terrier (unspecified) 1
Akita 1

Most Reported Reactions

Vomiting 6
Tachycardia 2
Seizure NOS 2
Lethargy (see also Central nervous system depression in 'Neurological') 2
Behavioural disorder NOS 2
Trembling 2
Death 2
Lack of efficacy - NOS 2
Bradycardia 1
Apnoea 1
Hyperthermia 1
INEFFECTIVE, LOSS OF EFFECT 1

Outcome Breakdown

Ongoing
9 (45.0%)
Recovered/Normal
5 (25.0%)
Died
3 (15.0%)
Outcome Unknown
3 (15.0%)

Clonidine Hcl Adverse Event Insights

20 reports name Clonidine Hcl; 3 recorded a death outcome (15.0% of reported events, not a population-level mortality rate). Active ingredient: Clonidine Hcl. Administration routes: Oral, Unknown.

By species: Dog (18 reports), Human (2 reports). By breed: Shepherd Dog - German (4), Terrier - Bull - American Pit (3), Unknown (2).

Leading clinical signs: Vomiting (6), Tachycardia (2), Seizure NOS (2), Lethargy (see also Central nervous system depression in 'Neurological') (2). Outcome, 20 coded reports: Ongoing leads at 45.0%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.