Drug profile

The FDA adverse-event record for Cimetidine

46 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Cimetidine. See the species affected, top reactions, and outcomes below.

46
adverse-event reports
10.9%
death-coded share
Dog
most-reported species
18
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
46
Total Reports
5
Deaths Reported
10.9%
Death Rate

Active Ingredients

Cimetidine

Administration Routes

OralUnknownSubcutaneous

Species Affected

Dog 40
Horse 2
Cat 2
Other Canids 1
Human 1

Most Affected Breeds

Retriever - Labrador 5
Terrier (unspecified) 2
Schnauzer - Miniature 2
Mountain Dog - Bernese 2
Dachshund - Miniature 2
Domestic Shorthair 2
Unknown 2
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 2
Boxer (German Boxer) 1
Shepherd Dog - German 1

Most Reported Reactions

Vomiting 18
Diarrhoea 11
Anorexia 8
Lethargy (see also Central nervous system depression in 'Neurological') 8
Elevated serum alkaline phosphatase (SAP) 7
Lack of efficacy - NOS 6
Elevated alanine aminotransferase (ALT) 6
Other abnormal test result NOS 5
Elevated blood urea nitrogen (BUN) 5
Seizure NOS 5
Elevated creatinine 5
Not eating 5

Outcome Breakdown

Ongoing
19 (41.3%)
Outcome Unknown
13 (28.3%)
Recovered/Normal
8 (17.4%)
Euthanized
3 (6.5%)
Died
2 (4.3%)
Recovered with Sequela
1 (2.2%)

Cimetidine Adverse Event Insights

46 reports name Cimetidine; 5 recorded a death outcome (10.9% of reported events, not a population-level mortality rate). Active ingredient: Cimetidine. Administration routes: Oral, Unknown, Subcutaneous.

By species: Dog (40 reports), Horse (2 reports), Cat (2 reports). By breed: Retriever - Labrador (5), Terrier (unspecified) (2), Schnauzer - Miniature (2).

Leading clinical signs: Vomiting (18), Diarrhoea (11), Anorexia (8), Lethargy (see also Central nervous system depression in 'Neurological') (8). Outcome, 46 coded reports: Ongoing leads at 41.3%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.