Drug profile

The FDA adverse-event record for Cimetidine

51 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Cimetidine. Species, reactions, and outcomes follow.

#1102 of 2,679
by report volume (all drugs)
51
adverse-event reports
13.7%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Cimetidine ranks #1098 of 2679 by total reports (51) and #408 of 1130 by death-coded share (13.7%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1098
This drug, reports of 2679
#408
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Cimetidine has 51 reports now versus 51 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Cimetidine changes

Signature read: death-coded report count at 7 is the most distinctive stamp on Cimetidine's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
51
Total Reports
7
Deaths Reported
13.7%
Death-coded share of reports

Active Ingredients

Cimetidine

Administration Routes

UnknownOralSubcutaneous

Species Affected

Dog 45
Horse 2
Cat 2
Other Canids 1
Human 1

Most Affected Breeds

Retriever - Labrador 5
Bulldog - French 4
Shih Tzu 3
Terrier (unspecified) 2
Schnauzer - Miniature 2
Mountain Dog - Bernese 2
Dachshund - Miniature 2
Domestic Shorthair 2
Unknown 2
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 2

Most Reported Reactions

Vomiting 18
Diarrhoea 11
Anorexia 8
Lethargy (see also Central nervous system depression in 'Neurological') 8
Elevated serum alkaline phosphatase (SAP) 7
Lack of efficacy - NOS 6
Elevated alanine aminotransferase (ALT) 6
Other abnormal test result NOS 5
Elevated blood urea nitrogen (BUN) 5
Death by euthanasia 5
Seizure NOS 5
Elevated creatinine 5

Outcome Breakdown

Ongoing
19 (37.3%)
Outcome Unknown
16 (31.4%)
Recovered/Normal
8 (15.7%)
Euthanized
5 (9.8%)
Died
2 (3.9%)
Recovered with Sequela
1 (2.0%)

Cimetidine Adverse Event Insights

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Nationwide drugs with similar profiles

Two openFDA-derived peer sets for Cimetidine, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Cimetidine (#1102 of 2,679 by report volume); death-coded 13.7%. PlainBreed drug row · death-coded report count stamp 7 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →