Drug profile

The FDA adverse-event record for Chlorhexidine Gluconate + Ketoconazole + Phytosphingosine Salicyloyl

91 FDA reports name Chlorhexidine Gluconate + Ketoconazole + Phytosphingosine Salicyloyl, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#816 of 2,679
by report volume (all drugs)
91
adverse-event reports
1.1%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Chlorhexidine Gluconate + Ketoconazole + Phytosphingosine Salicyloyl ranks #815 of 2679 by total reports (91) and #1061 of 1130 by death-coded share (1.1%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#815
This drug, reports of 2679
#1061
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Chlorhexidine Gluconate + Ketoconazole + Phytosphingosine Salicyloyl has 91 reports now versus 91 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Chlorhexidine Gluconate + Ketoconazole + Phytosphingosine Salicyloyl changes

Signature read: Chlorhexidine Gluconate + Ketoconazole + Phytosphingosine Salicyloyl's 1.1% death-coded share is among the lowest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
91
Total Reports
1
Deaths Reported
1.1%
Death-coded share of reports

Active Ingredients

Chlorhexidine GluconateKetoconazolePhytosphingosine Salicyloyl

Administration Routes

TopicalAuricular (Otic)

Species Affected

Dog 76
Cat 8
Human 7

Most Affected Breeds

Domestic Shorthair 7
Crossbred Canine/dog 7
Unknown 7
Shih Tzu 7
Mixed (Dog) 7
Dog (unknown) 6
Pit Bull 5
Terrier - West Highland White 3
Retriever - Labrador 3
Retriever - Golden 3

Most Reported Reactions

Application site hair coat discolouration 15
Application site erythema 14
Pruritus 7
Erythema (for urticaria see Immune SOC) 6
Color, Abnormal 6
Skin inflammation NOS 5
Application site irritation 4
Application site pruritus 4
Hypersalivation 4
Vomiting 3
Application site reddening 3
Emesis (multiple) 3

Outcome Breakdown

Recovered/Normal
53 (58.2%)
Ongoing
26 (28.6%)
Outcome Unknown
10 (11.0%)
Recovered with Sequela
1 (1.1%)
Died
1 (1.1%)

Chlorhexidine Gluconate + Ketoconazole + Phytosphingosine Salicyloyl: low death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Chlorhexidine Gluconate + Ketoconazole + Phytosphingosine Salicyloyl, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

  • Compare Chlorhexidine Gluconate + Ketoconazole + Phytosphingosine Salicyloyl's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Chlorhexidine Gluconate + Ketoconazole + Phytosphingosine Salicyloyl (#816 of 2,679 by report volume); death-coded 1.1%. PlainBreed drug row · death-coded share stamp 1.1% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →