Drug profile

The FDA adverse-event record for Chemotherapy Drug

52 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Chemotherapy Drug. See the species affected, top reactions, and outcomes below.

52
adverse-event reports
34.6%
death-coded share
Dog
most-reported species
10
Lethargy (see also Central nervous system depression in 'Neurological') - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
52
Total Reports
18
Deaths Reported
34.6%
Death Rate

Active Ingredients

Chemotherapy Drug

Administration Routes

UnknownOralIntravenous

Species Affected

Dog 41
Cat 11

Most Affected Breeds

Domestic Shorthair 6
Shih Tzu 3
Dog (unknown) 3
Terrier - Bull - American Pit 3
Crossbred Canine/dog 2
Collie - Border 2
Pug 2
Boxer (German Boxer) 2
Shepherd Dog - Australian 2
Retriever - Golden 2

Most Reported Reactions

Lethargy (see also Central nervous system depression in 'Neurological') 10
Death by euthanasia 9
Vomiting 8
Death 8
Anorexia 7
Lymphoma 6
Diarrhoea 5
Other abnormal test result NOS 5
Hypoalbuminaemia 5
Weakness 4
Lack of efficacy - NOS 4
Anaemia NOS 4

Outcome Breakdown

Ongoing
20 (38.5%)
Outcome Unknown
9 (17.3%)
Euthanized
9 (17.3%)
Died
9 (17.3%)
Recovered/Normal
5 (9.6%)

Chemotherapy Drug Adverse Event Insights

52 reports name Chemotherapy Drug; 18 recorded a death outcome (34.6% of reported events, not a population-level mortality rate). Active ingredient: Chemotherapy Drug. Administration routes: Unknown, Oral, Intravenous.

By species: Dog (41 reports), Cat (11 reports). By breed: Domestic Shorthair (6), Shih Tzu (3), Dog (unknown) (3).

Leading clinical signs: Lethargy (see also Central nervous system depression in 'Neurological') (10), Death by euthanasia (9), Vomiting (8), Death (8). Outcome, 52 coded reports: Ongoing leads at 38.5%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.