Drug profile

The FDA adverse-event record for Cerenia

65 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Cerenia. Species, reactions, and outcomes follow.

#971 of 2,679
by report volume (all drugs)
65
adverse-event reports
24.6%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Cerenia ranks #970 of 2679 by total reports (65) and #177 of 1130 by death-coded share (24.6%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#970
This drug, reports of 2679
#177
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Cerenia has 65 reports now versus 65 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Cerenia changes

Signature read: Cerenia's 24.6% death-coded share is among the highest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
65
Total Reports
16
Deaths Reported
24.6%
Death-coded share of reports

Active Ingredients

Cerenia

Administration Routes

UnknownSubcutaneousOralOther

Species Affected

Dog 53
Cat 12

Most Affected Breeds

Domestic Shorthair 8
Dog (unknown) 6
Retriever - Labrador 5
Crossbred Canine/dog 5
Schnauzer - Miniature 4
Terrier - Yorkshire 3
Boxer (German Boxer) 3
Chihuahua 3
Domestic Longhair 2
Terrier - Jack Russell 2

Most Reported Reactions

Lethargy (see also Central nervous system depression in 'Neurological') 18
Vomiting 15
Emesis (multiple) 14
Other abnormal test result NOS 13
Diarrhoea 10
Abnormal radiograph finding 10
Weight loss 8
Death 8
Death by euthanasia 7
Elevated serum alkaline phosphatase (SAP) 6
Not eating 6
Bloody diarrhoea 5

Outcome Breakdown

Ongoing
21 (32.3%)
Recovered/Normal
17 (26.2%)
Outcome Unknown
10 (15.4%)
Died
9 (13.8%)
Euthanized
7 (10.8%)
Recovered with Sequela
1 (1.5%)

Cerenia: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Nationwide drugs with similar profiles

Two openFDA-derived peer sets for Cerenia, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar report volume

Nearest other drugs by FDA report count (65 here).

Similar death-coded share

Nearest other drugs by death-coded share (24.6% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Cerenia (#971 of 2,679 by report volume); death-coded 24.6%. PlainBreed drug row · death-coded share stamp 24.6% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →