Drug profile

The FDA adverse-event record for Cephapirin Sodium

368 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Cephapirin Sodium. See the species affected, top reactions, and outcomes below.

368
adverse-event reports
1.4%
death-coded share
Cattle
most-reported species
179
Residues in milk - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
368
Total Reports
5
Deaths Reported
1.4%
Death Rate

Active Ingredients

Cephapirin Sodium

Administration Routes

IntramammaryUnknownOralTopicalIntramuscularIntralesional

Species Affected

Cattle 286
Unknown 74
Goat 3
Horse 2
Human 1
Dog 1
Sheep 1

Most Affected Breeds

Holstein-Friesian also known as Holstein 199
Unknown 78
Cattle (other) 48
Cattle (unknown) 15
Jersey 13
Crossbred Bovine/Cattle 6
Goat (unknown) 2
Tennessee Walking Horse 1
Goat (other) 1
Ayrshire 1

Most Reported Reactions

Residues in milk 179
Drug dose administration interval too long 74
INEFFECTIVE, ANTIBIOTIC 51
Lack of efficacy (bacteria) - NOS 43
Tubes, Damaged 16
Product syringe issue 13
Tubes, Abnormal 12
Containers, Damaged 12
Product Defect, General 11
Product problem 9
Drug administration duration too long 9
Uncoded sign 8

Outcome Breakdown

Recovered/Normal
139 (52.5%)
Outcome Unknown
113 (42.6%)
Ongoing
6 (2.3%)
Died
3 (1.1%)
Recovered with Sequela
2 (0.8%)
Euthanized
2 (0.8%)

Cephapirin Sodium Adverse Event Insights

368 reports name Cephapirin Sodium; 5 recorded a death outcome (1.4% of reported events, not a population-level mortality rate). Active ingredient: Cephapirin Sodium. Administration routes: Intramammary, Unknown, Oral, Topical.

By species: Cattle (286 reports), Unknown (74 reports), Goat (3 reports). By breed: Holstein-Friesian also known as Holstein (199), Unknown (78), Cattle (other) (48).

Leading clinical signs: Residues in milk (179), Drug dose administration interval too long (74), INEFFECTIVE, ANTIBIOTIC (51), Lack of efficacy (bacteria) - NOS (43). Outcome, 265 coded reports: Recovered/Normal leads at 52.5%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.