Drug profile

The FDA adverse-event record for Ceftiofur Sodium

551 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Ceftiofur Sodium. See the species affected, top reactions, and outcomes below.

551
adverse-event reports
8.2%
death-coded share
Unknown
most-reported species
141
Suspension, Abnormal - top reaction
Verify with FDA CVM →
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
551
Total Reports
45
Deaths Reported
8.2%
Death Rate

Active Ingredients

Ceftiofur Sodium

Administration Routes

UnknownSubcutaneousIntramuscularIntravenousOtherOralIntra-ArticularOphthalmicIntrauterineParenteral

Species Affected

Unknown 398
Dog 47
Cattle 44
Horse 35
Cat 12
Goat 3
Pig 3
Human 3
Sheep 3
Other 2

Most Affected Breeds

Unknown 403
Holstein-Friesian also known as Holstein 20
Cattle (other) 13
Horse (unknown) 9
Quarter Horse 7
Domestic Shorthair 7
Retriever - Labrador 5
Warmblood (unspecified) 5
Domestic (unspecified) 4
Cattle (unknown) 4

Most Reported Reactions

Suspension, Abnormal 141
Solution, Abnormal 127
Color, Abnormal 118
Precipitate, Sediment 108
No sign 37
Death 25
Uncoded sign 21
Lack of efficacy - NOS 20
Contamination, Foreign Object 19
Granules/Powder, Abnormal 16
Appearance, Abnormal 15
Residues in meat/offal 14

Outcome Breakdown

Outcome Unknown
42 (30.7%)
Died
29 (21.2%)
Ongoing
25 (18.2%)
Recovered/Normal
24 (17.5%)
Euthanized
17 (12.4%)

Ceftiofur Sodium Adverse Event Insights

551 reports name Ceftiofur Sodium; 45 recorded a death outcome (8.2% of reported events, not a population-level mortality rate). Active ingredient: Ceftiofur Sodium. Administration routes: Unknown, Subcutaneous, Intramuscular, Intravenous.

By species: Unknown (398 reports), Dog (47 reports), Cattle (44 reports). By breed: Unknown (403), Holstein-Friesian also known as Holstein (20), Cattle (other) (13).

Leading clinical signs: Suspension, Abnormal (141), Solution, Abnormal (127), Color, Abnormal (118), Precipitate, Sediment (108). Outcome, 137 coded reports: Outcome Unknown leads at 30.7%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.