Drug profile

The FDA adverse-event record for Cefpodoxime Proxetil

2,226 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Cefpodoxime Proxetil. See the species affected, top reactions, and outcomes below.

2,226
adverse-event reports
9.4%
death-coded share
Dog
most-reported species
406
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
2,226
Total Reports
210
Deaths Reported
9.4%
Death Rate

Active Ingredients

Cefpodoxime Proxetil

Administration Routes

OralUnknownSubcutaneousParenteralOtherTopicalOphthalmic

Species Affected

Dog 2,120
Unknown 70
Cat 34
Human 2

Most Affected Breeds

Retriever - Labrador 244
Retriever - Golden 110
Shepherd Dog - German 90
Crossbred Canine/dog 85
Unknown 75
Bulldog 75
Shih Tzu 70
Boxer (German Boxer) 65
Terrier - Bull - American Pit 61
Terrier - Yorkshire 50

Most Reported Reactions

Vomiting 406
Lethargy (see also Central nervous system depression in 'Neurological') 329
Emesis 190
Anorexia 187
Diarrhoea 165
Lack of efficacy - NOS 148
Other abnormal test result NOS 144
Seizure NOS 130
Elevated alanine aminotransferase (ALT) 126
Death by euthanasia 117
Elevated serum alkaline phosphatase (SAP) 112
Pruritus 94

Outcome Breakdown

Ongoing
872 (43.5%)
Recovered/Normal
559 (27.9%)
Outcome Unknown
333 (16.6%)
Died
107 (5.3%)
Euthanized
103 (5.1%)
Recovered with Sequela
29 (1.4%)

Cefpodoxime Proxetil Adverse Event Insights

2,226 reports name Cefpodoxime Proxetil; 210 recorded a death outcome (9.4% of reported events, not a population-level mortality rate). Active ingredient: Cefpodoxime Proxetil. Administration routes: Oral, Unknown, Subcutaneous, Parenteral.

By species: Dog (2,120 reports), Unknown (70 reports), Cat (34 reports). By breed: Retriever - Labrador (244), Retriever - Golden (110), Shepherd Dog - German (90).

Leading clinical signs: Vomiting (406), Lethargy (see also Central nervous system depression in 'Neurological') (329), Emesis (190), Anorexia (187). Outcome, 2,003 coded reports: Ongoing leads at 43.5%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.