Drug profile

The FDA adverse-event record for Cefpodoxime

1,142 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Cefpodoxime. See the species affected, top reactions, and outcomes below.

1,142
adverse-event reports
9.7%
death-coded share
Dog
most-reported species
179
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
1,142
Total Reports
111
Deaths Reported
9.7%
Death Rate

Active Ingredients

Cefpodoxime

Administration Routes

OralUnknownSubcutaneousTopical

Species Affected

Dog 1,112
Cat 21
Unknown 7
Human 2

Most Affected Breeds

Retriever - Labrador 137
Retriever - Golden 69
Shepherd Dog - German 69
Crossbred Canine/dog 57
Terrier - Bull - American Pit 43
Pit Bull 34
Shih Tzu 33
Boxer (German Boxer) 28
Beagle 25
Bulldog 24

Most Reported Reactions

Vomiting 179
Lethargy (see also Central nervous system depression in 'Neurological') 131
Lack of efficacy - NOS 116
Diarrhoea 99
Other abnormal test result NOS 98
Seizure NOS 76
Lethargy (see also Central nervous system depression in Neurological) 71
Anorexia 70
Death by euthanasia 66
Elevated alanine aminotransferase (ALT) 66
Emesis 65
Decreased appetite 58

Outcome Breakdown

Ongoing
493 (43.5%)
Recovered/Normal
284 (25.1%)
Outcome Unknown
231 (20.4%)
Euthanized
63 (5.6%)
Died
48 (4.2%)
Recovered with Sequela
14 (1.2%)

Cefpodoxime Adverse Event Insights

1,142 reports name Cefpodoxime; 111 recorded a death outcome (9.7% of reported events, not a population-level mortality rate). Active ingredient: Cefpodoxime. Administration routes: Oral, Unknown, Subcutaneous, Topical.

By species: Dog (1,112 reports), Cat (21 reports), Unknown (7 reports). By breed: Retriever - Labrador (137), Retriever - Golden (69), Shepherd Dog - German (69).

Leading clinical signs: Vomiting (179), Lethargy (see also Central nervous system depression in 'Neurological') (131), Lack of efficacy - NOS (116), Diarrhoea (99). Outcome, 1,133 coded reports: Ongoing leads at 43.5%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.