Drug profile

The FDA adverse-event record for Caninie Vaccine

297 FDA reports name Caninie Vaccine, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#424 of 2,679
by report volume (all drugs)
297
adverse-event reports
8.4%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Caninie Vaccine ranks #424 of 2679 by total reports (297) and #623 of 1130 by death-coded share (8.4%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#424
This drug, reports of 2679
#623
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Caninie Vaccine has 297 reports now versus 297 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Caninie Vaccine changes

Signature read: 297 reports place Caninie Vaccine in the upper third of FDA AER volume (#424 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
297
Total Reports
25
Deaths Reported
8.4%
Death-coded share of reports

Active Ingredients

Caninie Vaccine

Administration Routes

UnknownNasalOralSubcutaneous

Species Affected

Dog 297

Most Affected Breeds

Terrier - Bull - American Pit 35
Retriever - Labrador 22
Chihuahua 21
Boxer (German Boxer) 15
Terrier - Yorkshire 13
Schnauzer - Miniature 9
Dachshund (unspecified) 8
Terrier (unspecified) 8
Shih Tzu 7
Pug 7

Most Reported Reactions

Vomiting 124
Facial swelling (see also 'Skin') 89
Lethargy (see also Central nervous system depression in 'Neurological') 57
Hives (see also 'Skin') 49
Diarrhoea 42
Anaphylaxis 42
Pale mucous membrane 30
Urticaria 26
Fever 21
Anaphylactoid reaction 18
Seizure NOS 16
Pruritus 16

Outcome Breakdown

Ongoing
136 (45.8%)
Recovered/Normal
123 (41.4%)
Died
15 (5.1%)
Outcome Unknown
13 (4.4%)
Euthanized
10 (3.4%)

Caninie Vaccine: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Caninie Vaccine, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (8.4% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Caninie Vaccine (#424 of 2,679 by report volume); death-coded 8.4%. PlainBreed drug row · report volume stamp 297 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →