Drug profile

The FDA adverse-event record for Canine Lepto*4(Orig S-P Us) Kb

194 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Canine Lepto*4(Orig S-P Us) Kb. See the species affected, top reactions, and outcomes below.

194
adverse-event reports
16.5%
death-coded share
Dog
most-reported species
50
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
194
Total Reports
32
Deaths Reported
16.5%
Death Rate

Active Ingredients

Canine Lepto*4(Orig S-P Us) Kb

Administration Routes

SubcutaneousUnknown

Species Affected

Dog 194

Most Affected Breeds

Crossbred Canine/dog 56
Retriever - Labrador 17
Bulldog - French 7
Siberian Husky 6
Shepherd Dog - Australian 6
Chihuahua 5
Shih Tzu 5
Shepherd Dog - German 5
Maltese 5
Retriever - Golden 5

Most Reported Reactions

Vomiting 50
Emesis (multiple) 40
Lethargy (see also Central nervous system depression in 'Neurological') 37
Anorexia 23
Diarrhoea 22
Death by euthanasia 21
Other abnormal test result NOS 19
Neutrophilia 17
Fever 16
Lethargy (see also Central nervous system depression in Neurological) 16
Elevated alanine aminotransferase (ALT) 13
Not eating 13

Outcome Breakdown

Ongoing
75 (38.7%)
Recovered/Normal
67 (34.5%)
Euthanized
21 (10.8%)
Outcome Unknown
13 (6.7%)
Died
11 (5.7%)
Recovered with Sequela
7 (3.6%)

Canine Lepto*4(Orig S-P Us) Kb Adverse Event Insights

194 reports name Canine Lepto*4(Orig S-P Us) Kb; 32 recorded a death outcome (16.5% of reported events, not a population-level mortality rate). Active ingredient: Canine Lepto*4(Orig S-P Us) Kb. Administration routes: Subcutaneous, Unknown.

By species: Dog (194 reports). By breed: Crossbred Canine/dog (56), Retriever - Labrador (17), Bulldog - French (7).

Leading clinical signs: Vomiting (50), Emesis (multiple) (40), Lethargy (see also Central nervous system depression in 'Neurological') (37), Anorexia (23). Outcome, 194 coded reports: Ongoing leads at 38.7%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.