Drug profile

The FDA adverse-event record for Canine Distemper Virus + Adenovirus + Parvovirus + Parainfluenza Virus + Leptospira Vaccine

55 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Canine Distemper Virus + Adenovirus + Parvovirus + Parainfluenza Virus + Leptospira Vaccine. Species, reactions, and outcomes follow.

#1057 of 2,679
by report volume (all drugs)
55
adverse-event reports
7.3%
death-coded share
Dog
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Canine Distemper Virus + Adenovirus + Parvovirus + Parainfluenza Virus + Leptospira Vaccine ranks #1056 of 2679 by total reports (55) and #681 of 1130 by death-coded share (7.3%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1056
This drug, reports of 2679
#681
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Canine Distemper Virus + Adenovirus + Parvovirus + Parainfluenza Virus + Leptospira Vaccine has 55 reports now versus 55 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Canine Distemper Virus + Adenovirus + Parvovirus + Parainfluenza Virus + Leptospira Vaccine changes

Signature read: death-coded share at 7.3% is the most distinctive stamp on Canine Distemper Virus + Adenovirus + Parvovirus + Parainfluenza Virus + Leptospira Vaccine's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
55
Total Reports
4
Deaths Reported
7.3%
Death-coded share of reports

Active Ingredients

Canine Distemper Virus + Adenovirus + Parvovirus + Parainfluenza Virus + Leptospira Vaccine

Administration Routes

ParenteralUnknownSubcutaneous

Species Affected

Dog 55

Most Affected Breeds

Retriever - Labrador 11
Retriever - Golden 4
Shepherd Dog - German 3
Shepherd Dog - Australian 3
Shih Tzu 3
Pinscher - Miniature 2
Pug 2
Terrier - West Highland White 2
Pit Bull 2
Dog (unknown) 2

Most Reported Reactions

Vomiting 24
Lethargy (see also Central nervous system depression in 'Neurological') 12
Diarrhoea 9
Lack of efficacy (endoparasite) - heartworm 6
Emesis 4
Not eating 4
Behavioural disorder NOS 3
Anaemia NOS 3
Weight loss 3
Weakness 3
Other abnormal test result NOS 3
Decreased appetite 3

Outcome Breakdown

Recovered/Normal
22 (40.0%)
Outcome Unknown
13 (23.6%)
Ongoing
13 (23.6%)
Recovered with Sequela
3 (5.5%)
Died
2 (3.6%)
Euthanized
2 (3.6%)

Canine Distemper Virus + Adenovirus + Parvovirus + Parainfluenza Virus + Leptospira Vaccine Adverse Event Insights

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Nationwide drugs with similar profiles

Two openFDA-derived peer sets for Canine Distemper Virus + Adenovirus + Parvovirus + Parainfluenza Virus + Leptospira Vaccine, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar report volume

Nearest other drugs by FDA report count (55 here).

Bb Canine / Pi Lb/Lv 55 Capstar 55 Chinese Herbs 55 Dappl Vaccine 55

Similar death-coded share

Nearest other drugs by death-coded share (7.3% here), distinct from the volume row.

Dexmedetomidine Hydrochloride Injection 7.3% Eprinomectin + Esafoxolaner + Praziquantel 7.3% Omega 3 Fatty Acids 7.2% Allergy 7.3%

What to do with this drug

  • Compare Canine Distemper Virus + Adenovirus + Parvovirus + Parainfluenza Virus + Leptospira Vaccine's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Canine Distemper Virus + Adenovirus + Parvovirus + Parainfluenza Virus + Leptospira Vaccine (#1057 of 2,679 by report volume); death-coded 7.3%. PlainBreed drug row · death-coded share stamp 7.3% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →