Drug profile

The FDA adverse-event record for Canine Distemper Virus + Adenovirus + Parvovirus + Parainfluenza Virus + Leptospira Vaccine

55 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Canine Distemper Virus + Adenovirus + Parvovirus + Parainfluenza Virus + Leptospira Vaccine. See the species affected, top reactions, and outcomes below.

55
adverse-event reports
7.3%
death-coded share
Dog
most-reported species
24
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
55
Total Reports
4
Deaths Reported
7.3%
Death Rate

Active Ingredients

Canine Distemper Virus + Adenovirus + Parvovirus + Parainfluenza Virus + Leptospira Vaccine

Administration Routes

ParenteralUnknownSubcutaneous

Species Affected

Dog 55

Most Affected Breeds

Retriever - Labrador 11
Retriever - Golden 4
Shepherd Dog - German 3
Shepherd Dog - Australian 3
Shih Tzu 3
Pinscher - Miniature 2
Pug 2
Terrier - West Highland White 2
Pit Bull 2
Dog (unknown) 2

Most Reported Reactions

Vomiting 24
Lethargy (see also Central nervous system depression in 'Neurological') 12
Diarrhoea 9
Lack of efficacy (endoparasite) - heartworm 6
Emesis 4
Not eating 4
Behavioural disorder NOS 3
Anaemia NOS 3
Weight loss 3
Weakness 3
Other abnormal test result NOS 3
Decreased appetite 3

Outcome Breakdown

Recovered/Normal
22 (40.0%)
Outcome Unknown
13 (23.6%)
Ongoing
13 (23.6%)
Recovered with Sequela
3 (5.5%)
Died
2 (3.6%)
Euthanized
2 (3.6%)

Canine Distemper Virus + Adenovirus + Parvovirus + Parainfluenza Virus + Leptospira Vaccine Adverse Event Insights

55 reports name Canine Distemper Virus + Adenovirus + Parvovirus + Parainfluenza Virus + Leptospira Vaccine; 4 recorded a death outcome (7.3% of reported events, not a population-level mortality rate). Active ingredient: Canine Distemper Virus + Adenovirus + Parvovirus + Parainfluenza Virus + Leptospira Vaccine. Administration routes: Parenteral, Unknown, Subcutaneous.

By species: Dog (55 reports). By breed: Retriever - Labrador (11), Retriever - Golden (4), Shepherd Dog - German (3).

Leading clinical signs: Vomiting (24), Lethargy (see also Central nervous system depression in 'Neurological') (12), Diarrhoea (9), Lack of efficacy (endoparasite) - heartworm (6). Outcome, 55 coded reports: Recovered/Normal leads at 40.0%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.