Drug profile

The FDA adverse-event record for Canine Distemper Virus + Adenovirus + Parvovirus + Parainfluenza Virus

32 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Canine Distemper Virus + Adenovirus + Parvovirus + Parainfluenza Virus. See the species affected, top reactions, and outcomes below.

32
adverse-event reports
3.1%
death-coded share
Dog
most-reported species
10
Lack of efficacy (endoparasite) - heartworm - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
32
Total Reports
1
Deaths Reported
3.1%
Death Rate

Active Ingredients

Canine Distemper Virus + Adenovirus + Parvovirus + Parainfluenza Virus

Administration Routes

UnknownSubcutaneousParenteral

Species Affected

Dog 31
Cat 1

Most Affected Breeds

Retriever - Labrador 5
Shih Tzu 2
Shepherd Dog - Australian 2
Retriever - Golden 2
Terrier - Jack Russell 2
Great Pyrenees 2
Coonhound (unspecified) 2
Pug 1
Shepherd Dog - German 1
Spitz - German Pomeranian 1

Most Reported Reactions

Lack of efficacy (endoparasite) - heartworm 10
Vomiting 6
Other abnormal test result NOS 4
Not eating 4
Lack of efficacy (virus) - parvovirus (including feline panleukopenia) 3
Anxiety 3
Urine abnormalities NOS 3
Monocytosis 3
Diarrhoea 3
Elevated blood urea nitrogen (BUN) 3
Lethargy (see also Central nervous system depression in Neurological) 3
Head tremor 2

Outcome Breakdown

Outcome Unknown
19 (59.4%)
Ongoing
8 (25.0%)
Recovered/Normal
4 (12.5%)
Died
1 (3.1%)

Canine Distemper Virus + Adenovirus + Parvovirus + Parainfluenza Virus Adverse Event Insights

32 reports name Canine Distemper Virus + Adenovirus + Parvovirus + Parainfluenza Virus; 1 recorded a death outcome (3.1% of reported events, not a population-level mortality rate). Active ingredient: Canine Distemper Virus + Adenovirus + Parvovirus + Parainfluenza Virus. Administration routes: Unknown, Subcutaneous, Parenteral.

By species: Dog (31 reports), Cat (1 reports). By breed: Retriever - Labrador (5), Shih Tzu (2), Shepherd Dog - Australian (2).

Leading clinical signs: Lack of efficacy (endoparasite) - heartworm (10), Vomiting (6), Other abnormal test result NOS (4), Not eating (4). Outcome, 32 coded reports: Outcome Unknown leads at 59.4%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.