Drug profile

The FDA adverse-event record for Canine Distemper-Adenovirus Type 2-Parvovirus Vaccine, Modified Live Virus, Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract

182 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Canine Distemper-Adenovirus Type 2-Parvovirus Vaccine, Modified Live Virus, Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract. See the species affected, top reactions, and outcomes below.

182
adverse-event reports
13.7%
death-coded share
Dog
most-reported species
47
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
182
Total Reports
25
Deaths Reported
13.7%
Death Rate

Active Ingredients

Canine Distemper-Adenovirus Type 2-Parvovirus Vaccine, Modified Live Virus, Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract

Administration Routes

SubcutaneousParenteralUnknown

Species Affected

Dog 182

Most Affected Breeds

Retriever - Labrador 25
Retriever - Golden 12
Shepherd Dog - Australian 10
Shepherd Dog - German 10
Boxer (German Boxer) 9
Terrier - Yorkshire 7
Schnauzer - Miniature 6
Dachshund - Miniature 5
Shih Tzu 5
Bulldog - French 5

Most Reported Reactions

Vomiting 47
Lethargy (see also Central nervous system depression in 'Neurological') 24
Diarrhoea 23
Lack of efficacy (virus) - parvovirus (including feline panleukopenia) 21
Facial swelling (see also 'Skin') 18
Other abnormal test result NOS 17
Pale mucous membrane 17
Lethargy (see also Central nervous system depression in Neurological) 15
Not eating 14
Death 12
Lack of efficacy - NOS 11
Death by euthanasia 10

Outcome Breakdown

Recovered/Normal
67 (36.8%)
Outcome Unknown
60 (33.0%)
Ongoing
28 (15.4%)
Died
15 (8.2%)
Euthanized
10 (5.5%)
Recovered with Sequela
2 (1.1%)

Canine Distemper-Adenovirus Type 2-Parvovirus Vaccine, Modified Live Virus, Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract Adverse Event Insights

182 reports name Canine Distemper-Adenovirus Type 2-Parvovirus Vaccine, Modified Live Virus, Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract; 25 recorded a death outcome (13.7% of reported events, not a population-level mortality rate). Active ingredient: Canine Distemper-Adenovirus Type 2-Parvovirus Vaccine, Modified Live Virus, Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract. Administration routes: Subcutaneous, Parenteral, Unknown.

By species: Dog (182 reports). By breed: Retriever - Labrador (25), Retriever - Golden (12), Shepherd Dog - Australian (10).

Leading clinical signs: Vomiting (47), Lethargy (see also Central nervous system depression in 'Neurological') (24), Diarrhoea (23), Lack of efficacy (virus) - parvovirus (including feline panleukopenia) (21). Outcome, 182 coded reports: Recovered/Normal leads at 36.8%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.