Drug profile

The FDA adverse-event record for Canine Distemper + Adenovirus Type 2 + Parainfluenza + Parvovirus Vaccine

Name: Canine Distemper + Adenovirus Type 2 + Parainfluenza + Parvovirus Vaccine - FDA Animal Adverse Event Reports
Creator: PlainBreed
License: https://creativecommons.org/publicdomain/zero/1.0/

84 FDA reports name Canine Distemper + Adenovirus Type 2 + Parainfluenza + Parvovirus Vaccine, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#858 of 2,679
by report volume (all drugs): 84
adverse-event reports: 9.5%
death-coded share: Dog
most-reported species

Compiled by PlainBreed

Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Canine Distemper + Adenovirus Type 2 + Parainfluenza + Parvovirus Vaccine ranks #858 of 2679 by total reports (84) and #561 of 1130 by death-coded share (9.5%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1): 97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1): #858
This drug, reports of 2679: #561
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Canine Distemper + Adenovirus Type 2 + Parainfluenza + Parvovirus Vaccine has 84 reports now versus 83 in that prior snapshot: 1 more (1.2%).

Report change: +1
Death-coded reports: +0
Death-coded share: −0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Canine Distemper + Adenovirus Type 2 + Parainfluenza + Parvovirus Vaccine changes

Signature read: 84 reports place Canine Distemper + Adenovirus Type 2 + Parainfluenza + Parvovirus Vaccine in the upper third of FDA AER volume (#858 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.

Total Reports

Deaths Reported

9.5%

Death-coded share of reports

Active Ingredients

Canine Distemper + Adenovirus Type 2 + Parainfluenza + Parvovirus Vaccine

Administration Routes

UnknownParenteralSubcutaneousOther

Species Affected

Dog 84

Most Affected Breeds

Retriever - Labrador 13

Retriever - Golden 7

Chihuahua 6

Crossbred Canine/dog 6

Beagle 4

Shih Tzu 3

Terrier - Jack Russell 3

Retriever (unspecified) 2

Pit Bull 2

Terrier - Yorkshire 2

Most Reported Reactions

Vomiting 18

Lethargy (see also Central nervous system depression in 'Neurological') 13

Diarrhoea 13

Seizure NOS 9

Lack of efficacy (endoparasite) - heartworm 9

Other abnormal test result NOS 8

Behavioural disorder NOS 6

Lack of efficacy - NOS 6

Monocytosis 5

Lack of efficacy (virus) - parvovirus (including feline panleukopenia) 5

Weakness 4

Death by euthanasia 4

Outcome Breakdown

Outcome Unknown

32 (38.1%)

Recovered/Normal

29 (34.5%)

Ongoing

14 (16.7%)

Euthanized

4 (4.8%)

Died

4 (4.8%)

Recovered with Sequela

1 (1.2%)

Canine Distemper + Adenovirus Type 2 + Parainfluenza + Parvovirus Vaccine: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Canine Distemper + Adenovirus Type 2 + Parainfluenza + Parvovirus Vaccine, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar report volume

Nearest other drugs by FDA report count (84 here).

Merial La Polypropylene Syringe 84 Apoquel 85 Baytril 85 Bordetella, Parainfluenza, Adenovirus 85

Similar death-coded share

Nearest other drugs by death-coded share (9.5% here), distinct from the volume row.

Medetomidine Hydrochloride 9.5% Probiotic Supplement 9.5% Recombitek 4 Lepto - 2668.00 9.5% Bravecto 9.5%

What to do with this drug

Compare Canine Distemper + Adenovirus Type 2 + Parainfluenza + Parvovirus Vaccine's report volume and death-coded share against similar drugs nationwide. See similar drugs
Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Canine Distemper + Adenovirus Type 2 + Parainfluenza + Parvovirus Vaccine (#858 of 2,679 by report volume); death-coded 9.5%. PlainBreed drug row · report volume stamp 84 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →