Drug profile

The FDA adverse-event record for Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Vaccine, Modified Live And Killed Virus

29 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Vaccine, Modified Live And Killed Virus. Species, reactions, and outcomes follow.

#1467 of 2,679
by report volume (all drugs)
29
adverse-event reports
44.8%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Vaccine, Modified Live And Killed Virus ranks #1463 of 2679 by total reports (29). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1463
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Vaccine, Modified Live And Killed Virus has 29 reports now versus 29 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Vaccine, Modified Live And Killed Virus changes

Signature read: Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Vaccine, Modified Live And Killed Virus's 44.8% death-coded share is among the highest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
29
Total Reports
13
Deaths Reported
44.8%
Death-coded share of reports

Active Ingredients

Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Vaccine, Modified Live And Killed Virus

Administration Routes

SubcutaneousParenteralUnknown

Species Affected

Dog 29

Most Affected Breeds

Crossbred Canine/dog 4
Retriever - Golden 3
Poodle - Toy 3
Shih Tzu 3
Retriever - Labrador 2
Boxer (German Boxer) 2
Chihuahua 2
Pit Bull 1
Shepherd Dog - Australian 1
Maltese 1

Most Reported Reactions

Vomiting 10
Death 10
Other abnormal test result NOS 6
Lack of efficacy (virus) - parvovirus (including feline panleukopenia) 6
Diarrhoea 4
Seizure NOS 3
Not eating 3
Lethargy (see also Central nervous system depression in 'Neurological') 3
Elevated serum alkaline phosphatase (SAP) 3
Walking difficulty 2
Low platelet count 2
Platelet disorder NOS 2

Outcome Breakdown

Died
11 (37.9%)
Recovered/Normal
10 (34.5%)
Outcome Unknown
4 (13.8%)
Ongoing
2 (6.9%)
Euthanized
2 (6.9%)

Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Vaccine, Modified Live And Killed Virus: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Vaccine, Modified Live And Killed Virus (#1467 of 2,679 by report volume); death-coded 44.8%. PlainBreed drug row · death-coded share stamp 44.8% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →