Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Vaccine, Modified Live And Killed Virus

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29 adverse event reports submitted to the FDA

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
29
Total Reports
13
Deaths Reported
4480.0%
Death Rate

Active Ingredients

Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Vaccine, Modified Live And Killed Virus

Administration Routes

SubcutaneousParenteralUnknown

Species Affected

Dog 29

Most Affected Breeds

Crossbred Canine/dog 4
Retriever - Golden 3
Poodle - Toy 3
Shih Tzu 3
Retriever - Labrador 2
Boxer (German Boxer) 2
Chihuahua 2
Pit Bull 1
Maltese 1
Shepherd Dog - Australian 1

Most Reported Reactions

Vomiting 10
Death 10
Other abnormal test result NOS 6
Lack of efficacy (virus) - parvovirus (including feline panleukopenia) 6
Diarrhoea 4
Seizure NOS 3
Not eating 3
Lethargy (see also Central nervous system depression in 'Neurological') 3
Elevated serum alkaline phosphatase (SAP) 3
Walking difficulty 2
Low platelet count 2
Platelet disorder NOS 2

Outcome Breakdown

Died
11 (37.9%)
Recovered/Normal
10 (34.5%)
Outcome Unknown
4 (13.8%)
Ongoing
2 (6.9%)
Euthanized
2 (6.9%)

Data Summary

Metric Value
Total adverse event reports 29
Reports involving death 13
Case-fatality rate (reported events) 4480.0%
Distinct species in reports 1
Distinct breeds in reports 17
Distinct reactions reported 20
Active ingredients on file 1

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER). Counts reflect voluntary reports only.

Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Vaccine, Modified Live And Killed Virus Adverse Event Insights

The FDA Center for Veterinary Medicine database currently holds 29 adverse event reports referencing Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Vaccine, Modified Live And Killed Virus, including 13 reports in which the animal died — a 4480.0% case-fatality figure among reported events only, not a population-level mortality rate. Active ingredient on file: Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Vaccine, Modified Live And Killed Virus. Reported administration routes include Subcutaneous, Parenteral, Unknown. These numbers reflect voluntary submissions from pet owners, veterinarians, and manufacturers and therefore under-represent mild events and over-represent severe ones — a pattern the FDA has documented repeatedly for pharmacovigilance datasets.

The species most frequently named in Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Vaccine, Modified Live And Killed Virus reports are Dog (29 reports), with Dog accounting for the largest share. Within those species, Crossbred Canine/dog (4), Retriever - Golden (3), Poodle - Toy (3) appear most often — though breed popularity and ownership density shape these counts as much as any drug-specific sensitivity. This distribution matters because the same active ingredient can behave very differently across body sizes, ages, and species physiology.

The most commonly reported clinical signs associated with Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Vaccine, Modified Live And Killed Virus are Vomiting (10), Death (10), Other abnormal test result NOS (6), Lack of efficacy (virus) - parvovirus (including feline panleukopenia) (6). Of the 29 reports with a coded outcome, Died is the leading category at 37.9%. Because FDA adverse event data describes correlation rather than causation, these figures are best used to frame informed questions with a veterinarian and to compare reporting patterns across related products — not as a standalone safety verdict on Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Vaccine, Modified Live And Killed Virus.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

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Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial