Drug profile

The FDA adverse-event record for Buprenorphine,Ketamine,Dexmedetomidine

21 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Buprenorphine,Ketamine,Dexmedetomidine. See the species affected, top reactions, and outcomes below.

21
adverse-event reports
14.3%
death-coded share
Cat
most-reported species
6
Dilated pupils - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
21
Total Reports
3
Deaths Reported
14.3%
Death Rate

Active Ingredients

Buprenorphine,Ketamine,Dexmedetomidine

Administration Routes

UnknownParenteralIntramuscular

Species Affected

Cat 21

Most Affected Breeds

Domestic Shorthair 12
Siamese 3
Domestic Longhair 3
Bengal 2
Domestic Mediumhair 1

Most Reported Reactions

Dilated pupils 6
Behavioural disorder NOS 5
Lethargy (see also Central nervous system depression in Neurological) 3
Panting 3
Elevated temperature 3
Not sleeping 3
Lack of efficacy - NOS 3
Ataxia 3
Heart murmur 3
Agitation 2
Quiet 2
Rolling 2

Outcome Breakdown

Recovered/Normal
8 (38.1%)
Ongoing
6 (28.6%)
Outcome Unknown
4 (19.0%)
Died
3 (14.3%)

Buprenorphine,Ketamine,Dexmedetomidine Adverse Event Insights

21 reports name Buprenorphine,Ketamine,Dexmedetomidine; 3 recorded a death outcome (14.3% of reported events, not a population-level mortality rate). Active ingredient: Buprenorphine,Ketamine,Dexmedetomidine. Administration routes: Unknown, Parenteral, Intramuscular.

By species: Cat (21 reports). By breed: Domestic Shorthair (12), Siamese (3), Domestic Longhair (3).

Leading clinical signs: Dilated pupils (6), Behavioural disorder NOS (5), Lethargy (see also Central nervous system depression in Neurological) (3), Panting (3). Outcome, 21 coded reports: Recovered/Normal leads at 38.1%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.