Drug profile

The FDA adverse-event record for Bupivicaine

35 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Bupivicaine. See the species affected, top reactions, and outcomes below.

35
adverse-event reports
28.6%
death-coded share
Dog
most-reported species
6
Death - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
35
Total Reports
10
Deaths Reported
28.6%
Death Rate

Active Ingredients

Bupivicaine

Administration Routes

UnknownOtherParenteralIntra-ArticularTopicalIntralesionalIntradermalSubcutaneous

Species Affected

Dog 22
Cat 13

Most Affected Breeds

Domestic Shorthair 7
Domestic Mediumhair 4
Maltese 3
Crossbred Canine/dog 3
Dog (unknown) 3
Shih Tzu 2
Cat (unknown) 2
Terrier - Yorkshire 2
Boxer (German Boxer) 1
Terrier - Boston 1

Most Reported Reactions

Death 6
Hyperphosphataemia 6
Elevated creatinine 5
Vomiting 5
Not eating 5
Other abnormal test result NOS 4
Seizure NOS 4
Elevated alanine aminotransferase (ALT) 4
Not drinking 4
Proteinuria 4
Elevated symmetrical dimethylarginine (SDMA) 4
Death by euthanasia 4

Outcome Breakdown

Recovered/Normal
12 (34.3%)
Ongoing
7 (20.0%)
Died
6 (17.1%)
Outcome Unknown
6 (17.1%)
Euthanized
4 (11.4%)

Bupivicaine Adverse Event Insights

35 reports name Bupivicaine; 10 recorded a death outcome (28.6% of reported events, not a population-level mortality rate). Active ingredient: Bupivicaine. Administration routes: Unknown, Other, Parenteral, Intra-Articular.

By species: Dog (22 reports), Cat (13 reports). By breed: Domestic Shorthair (7), Domestic Mediumhair (4), Maltese (3).

Leading clinical signs: Death (6), Hyperphosphataemia (6), Elevated creatinine (5), Vomiting (5). Outcome, 35 coded reports: Recovered/Normal leads at 34.3%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.