Drug profile

The FDA adverse-event record for Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza3-Respiratory Syncytial Virus Vaccine, Modified Live Virus, Mannheimia Haemolytica Toxoid

44 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza3-Respiratory Syncytial Virus Vaccine, Modified Live Virus, Mannheimia Haemolytica Toxoid. See the species affected, top reactions, and outcomes below.

44
adverse-event reports
84.1%
death-coded share
Cattle
most-reported species
36
Death - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
44
Total Reports
37
Deaths Reported
84.1%
Death Rate

Active Ingredients

Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza3-Respiratory Syncytial Virus Vaccine, Modified Live Virus, Mannheimia Haemolytica Toxoid

Administration Routes

SubcutaneousSubconjunctivalUnknown

Species Affected

Cattle 44

Most Affected Breeds

Cattle (other) 28
Crossbred Bovine/Cattle 8
Aberdeen Angus 5
Holstein-Friesian also known as Holstein 2
Cattle (unknown) 1

Most Reported Reactions

Death 36
Respiratory signs 13
Lack of efficacy - NOS 13
NT - Abnormal necropsy finding NOS 8
Anorexia 7
Death by euthanasia 7
Pneumonia 6
Lethargy (see also Central nervous system depression in 'Neurological') 6
Fever 6
Other abnormal test result NOS 5
Nasal discharge 4
Lack of efficacy (bacteria) - NOS 4

Outcome Breakdown

Died
36 (48.6%)
Recovered/Normal
19 (25.7%)
Ongoing
8 (10.8%)
Euthanized
6 (8.1%)
Outcome Unknown
4 (5.4%)
Recovered with Sequela
1 (1.4%)

Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza3-Respiratory Syncytial Virus Vaccine, Modified Live Virus, Mannheimia Haemolytica Toxoid Adverse Event Insights

44 reports name Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza3-Respiratory Syncytial Virus Vaccine, Modified Live Virus, Mannheimia Haemolytica Toxoid; 37 recorded a death outcome (84.1% of reported events, not a population-level mortality rate). Active ingredient: Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza3-Respiratory Syncytial Virus Vaccine, Modified Live Virus, Mannheimia Haemolytica Toxoid. Administration routes: Subcutaneous, Subconjunctival, Unknown.

By species: Cattle (44 reports). By breed: Cattle (other) (28), Crossbred Bovine/Cattle (8), Aberdeen Angus (5).

Leading clinical signs: Death (36), Respiratory signs (13), Lack of efficacy - NOS (13), NT - Abnormal necropsy finding NOS (8). Outcome, 74 coded reports: Died leads at 48.6%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.