Drug profile

The FDA adverse-event record for Bovine Parainfluenza 3 Virus, Modified Live Virus + Bovine Respiratory Syncytial Virus, Modified Live Virus + Bovine Rhinotracheitis Virus, Modified Live Virus + Bovine Virus Diarrhea, Modified Live Virus + Leptospira Canicola Bacterin + Leptospira Grippotyphosa Bacterin + Leptospira Hardjo Bacterin + Leptospira Icterohaemorrhagiae Bacterin + Leptospira Pomona Bacterin

16 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Bovine Parainfluenza 3 Virus, Modified Live Virus + Bovine Respiratory Syncytial Virus, Modified Live Virus + Bovine Rhinotracheitis Virus, Modified Live Virus + Bovine Virus Diarrhea, Modified Live Virus + Leptospira Canicola Bacterin + Leptospira Grippotyphosa Bacterin + Leptospira Hardjo Bacterin + Leptospira Icterohaemorrhagiae Bacterin + Leptospira Pomona Bacterin. See the species affected, top reactions, and outcomes below.

16
adverse-event reports
81.3%
death-coded share
Cattle
most-reported species
11
Death - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
16
Total Reports
13
Deaths Reported
81.3%
Death Rate

Active Ingredients

Bovine Parainfluenza 3 Virus, Modified Live VirusBovine Respiratory Syncytial Virus, Modified Live VirusBovine Rhinotracheitis Virus, Modified Live VirusBovine Virus Diarrhea, Modified Live VirusLeptospira Canicola BacterinLeptospira Grippotyphosa BacterinLeptospira Hardjo BacterinLeptospira Icterohaemorrhagiae BacterinLeptospira Pomona Bacterin

Administration Routes

UnknownSubcutaneousIntrauterine

Species Affected

Cattle 16

Most Affected Breeds

Cattle (other) 7
Cattle (unknown) 3
Charolais 3
Holstein-Friesian also known as Holstein 2
Red Angus 1

Most Reported Reactions

Death 11
Lack of efficacy - NOS 8
Necropsy performed 4
Lack of efficacy (virus) - bovine viral diarrhoea virus 2
Respiratory signs 1
INEFFECTIVE, ANTIBIOTIC 1
Tachypnoea 1
Fever 1
Anorexia 1
Lung sound 1
Laboured breathing 1
Abnormal necropsy finding 1

Outcome Breakdown

Died
12 (48.0%)
Outcome Unknown
5 (20.0%)
Recovered/Normal
5 (20.0%)
Ongoing
2 (8.0%)
Euthanized
1 (4.0%)

Bovine Parainfluenza 3 Virus, Modified Live Virus + Bovine Respiratory Syncytial Virus, Modified Live Virus + Bovine Rhinotracheitis Virus, Modified Live Virus + Bovine Virus Diarrhea, Modified Live Virus + Leptospira Canicola Bacterin + Leptospira Grippotyphosa Bacterin + Leptospira Hardjo Bacterin + Leptospira Icterohaemorrhagiae Bacterin + Leptospira Pomona Bacterin Adverse Event Insights

16 reports name Bovine Parainfluenza 3 Virus, Modified Live Virus + Bovine Respiratory Syncytial Virus, Modified Live Virus + Bovine Rhinotracheitis Virus, Modified Live Virus + Bovine Virus Diarrhea, Modified Live Virus + Leptospira Canicola Bacterin + Leptospira Grippotyphosa Bacterin + Leptospira Hardjo Bacterin + Leptospira Icterohaemorrhagiae Bacterin + Leptospira Pomona Bacterin; 13 recorded a death outcome (81.3% of reported events, not a population-level mortality rate). Active ingredients: Bovine Parainfluenza 3 Virus, Modified Live Virus, Bovine Respiratory Syncytial Virus, Modified Live Virus, Bovine Rhinotracheitis Virus, Modified Live Virus, Bovine Virus Diarrhea, Modified Live Virus, Leptospira Canicola Bacterin. Administration routes: Unknown, Subcutaneous, Intrauterine.

By species: Cattle (16 reports). By breed: Cattle (other) (7), Cattle (unknown) (3), Charolais (3).

Leading clinical signs: Death (11), Lack of efficacy - NOS (8), Necropsy performed (4), Lack of efficacy (virus) - bovine viral diarrhoea virus (2). Outcome, 25 coded reports: Died leads at 48.0%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.