Bovine Parainfluenza 3 Virus, Modified Live Virus + Bovine Respiratory Syncytial Virus, Modified Live Virus + Bovine Rhinotracheitis Virus, Modified Live Virus + Bovine Virus Diarrhea Type 1, Modified Live Virus + Bovine Virus Diarrhea Type 2, Modified Live Virus

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87 adverse event reports submitted to the FDA

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
87
Total Reports
78
Deaths Reported
8970.0%
Death Rate

Active Ingredients

Bovine Parainfluenza 3 Virus, Modified Live VirusBovine Respiratory Syncytial Virus, Modified Live VirusBovine Rhinotracheitis Virus, Modified Live VirusBovine Virus Diarrhea Type 1, Modified Live VirusBovine Virus Diarrhea Type 2, Modified Live Virus

Administration Routes

UnknownSubcutaneousIntramuscular

Species Affected

Cattle 87

Most Affected Breeds

Cattle (other) 55
Aberdeen Angus 15
Crossbred Bovine/Cattle 7
Cattle (unknown) 6
Holstein-Friesian also known as Holstein 4

Most Reported Reactions

Death 76
Lack of efficacy - NOS 35
Lack of efficacy (bacteria) - NOS 16
Lack of efficacy (virus) - NOS 8
Anaphylaxis 7
Foaming at the mouth 5
Necropsy performed 5
Respiratory signs 4
INEFFECTIVE, ANTIBIOTIC 4
Lack of efficacy (bacteria NOS) 4
Other abnormal test result NOS 3
CULTURE/TITER DATA ABNORMAL 3

Outcome Breakdown

Died
78 (52.0%)
Outcome Unknown
29 (19.3%)
Recovered/Normal
22 (14.7%)
Ongoing
14 (9.3%)
Recovered with Sequela
4 (2.7%)
Euthanized
3 (2.0%)

Data Summary

Metric Value
Total adverse event reports 87
Reports involving death 78
Case-fatality rate (reported events) 8970.0%
Distinct species in reports 1
Distinct breeds in reports 5
Distinct reactions reported 20
Active ingredients on file 5

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER). Counts reflect voluntary reports only.

Bovine Parainfluenza 3 Virus, Modified Live Virus + Bovine Respiratory Syncytial Virus, Modified Live Virus + Bovine Rhinotracheitis Virus, Modified Live Virus + Bovine Virus Diarrhea Type 1, Modified Live Virus + Bovine Virus Diarrhea Type 2, Modified Live Virus Adverse Event Insights

The FDA Center for Veterinary Medicine database currently holds 87 adverse event reports referencing Bovine Parainfluenza 3 Virus, Modified Live Virus + Bovine Respiratory Syncytial Virus, Modified Live Virus + Bovine Rhinotracheitis Virus, Modified Live Virus + Bovine Virus Diarrhea Type 1, Modified Live Virus + Bovine Virus Diarrhea Type 2, Modified Live Virus, including 78 reports in which the animal died — a 8970.0% case-fatality figure among reported events only, not a population-level mortality rate. Active ingredients on file: Bovine Parainfluenza 3 Virus, Modified Live Virus, Bovine Respiratory Syncytial Virus, Modified Live Virus, Bovine Rhinotracheitis Virus, Modified Live Virus, Bovine Virus Diarrhea Type 1, Modified Live Virus, Bovine Virus Diarrhea Type 2, Modified Live Virus. Reported administration routes include Unknown, Subcutaneous, Intramuscular. These numbers reflect voluntary submissions from pet owners, veterinarians, and manufacturers and therefore under-represent mild events and over-represent severe ones — a pattern the FDA has documented repeatedly for pharmacovigilance datasets.

The species most frequently named in Bovine Parainfluenza 3 Virus, Modified Live Virus + Bovine Respiratory Syncytial Virus, Modified Live Virus + Bovine Rhinotracheitis Virus, Modified Live Virus + Bovine Virus Diarrhea Type 1, Modified Live Virus + Bovine Virus Diarrhea Type 2, Modified Live Virus reports are Cattle (87 reports), with Cattle accounting for the largest share. Within those species, Cattle (other) (55), Aberdeen Angus (15), Crossbred Bovine/Cattle (7) appear most often — though breed popularity and ownership density shape these counts as much as any drug-specific sensitivity. This distribution matters because the same active ingredient can behave very differently across body sizes, ages, and species physiology.

The most commonly reported clinical signs associated with Bovine Parainfluenza 3 Virus, Modified Live Virus + Bovine Respiratory Syncytial Virus, Modified Live Virus + Bovine Rhinotracheitis Virus, Modified Live Virus + Bovine Virus Diarrhea Type 1, Modified Live Virus + Bovine Virus Diarrhea Type 2, Modified Live Virus are Death (76), Lack of efficacy - NOS (35), Lack of efficacy (bacteria) - NOS (16), Lack of efficacy (virus) - NOS (8). Of the 150 reports with a coded outcome, Died is the leading category at 52.0%. Because FDA adverse event data describes correlation rather than causation, these figures are best used to frame informed questions with a veterinarian and to compare reporting patterns across related products — not as a standalone safety verdict on Bovine Parainfluenza 3 Virus, Modified Live Virus + Bovine Respiratory Syncytial Virus, Modified Live Virus + Bovine Rhinotracheitis Virus, Modified Live Virus + Bovine Virus Diarrhea Type 1, Modified Live Virus + Bovine Virus Diarrhea Type 2, Modified Live Virus.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial