Drug profile

The FDA adverse-event record for Bovine Parainfluenza 3 Virus, Modified Live Virus + Bovine Respiratory Syncytial Virus, Modified Live Virus + Bovine Rhinotracheitis Virus, Modified Live Virus + Bovine Virus Diarrhea Type 1, Modified Live Virus + Bovine Virus Diarrhea Type 2, Modified Live Virus

87 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Bovine Parainfluenza 3 Virus, Modified Live Virus + Bovine Respiratory Syncytial Virus, Modified Live Virus + Bovine Rhinotracheitis Virus, Modified Live Virus + Bovine Virus Diarrhea Type 1, Modified Live Virus + Bovine Virus Diarrhea Type 2, Modified Live Virus. See the species affected, top reactions, and outcomes below.

87
adverse-event reports
89.7%
death-coded share
Cattle
most-reported species
76
Death - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
87
Total Reports
78
Deaths Reported
89.7%
Death Rate

Active Ingredients

Bovine Parainfluenza 3 Virus, Modified Live VirusBovine Respiratory Syncytial Virus, Modified Live VirusBovine Rhinotracheitis Virus, Modified Live VirusBovine Virus Diarrhea Type 1, Modified Live VirusBovine Virus Diarrhea Type 2, Modified Live Virus

Administration Routes

UnknownSubcutaneousIntramuscular

Species Affected

Cattle 87

Most Affected Breeds

Cattle (other) 55
Aberdeen Angus 15
Crossbred Bovine/Cattle 7
Cattle (unknown) 6
Holstein-Friesian also known as Holstein 4

Most Reported Reactions

Death 76
Lack of efficacy - NOS 35
Lack of efficacy (bacteria) - NOS 16
Lack of efficacy (virus) - NOS 8
Anaphylaxis 7
Foaming at the mouth 5
Necropsy performed 5
Respiratory signs 4
INEFFECTIVE, ANTIBIOTIC 4
Lack of efficacy (bacteria NOS) 4
Other abnormal test result NOS 3
CULTURE/TITER DATA ABNORMAL 3

Outcome Breakdown

Died
78 (52.0%)
Outcome Unknown
29 (19.3%)
Recovered/Normal
22 (14.7%)
Ongoing
14 (9.3%)
Recovered with Sequela
4 (2.7%)
Euthanized
3 (2.0%)

Bovine Parainfluenza 3 Virus, Modified Live Virus + Bovine Respiratory Syncytial Virus, Modified Live Virus + Bovine Rhinotracheitis Virus, Modified Live Virus + Bovine Virus Diarrhea Type 1, Modified Live Virus + Bovine Virus Diarrhea Type 2, Modified Live Virus Adverse Event Insights

87 reports name Bovine Parainfluenza 3 Virus, Modified Live Virus + Bovine Respiratory Syncytial Virus, Modified Live Virus + Bovine Rhinotracheitis Virus, Modified Live Virus + Bovine Virus Diarrhea Type 1, Modified Live Virus + Bovine Virus Diarrhea Type 2, Modified Live Virus; 78 recorded a death outcome (89.7% of reported events, not a population-level mortality rate). Active ingredients: Bovine Parainfluenza 3 Virus, Modified Live Virus, Bovine Respiratory Syncytial Virus, Modified Live Virus, Bovine Rhinotracheitis Virus, Modified Live Virus, Bovine Virus Diarrhea Type 1, Modified Live Virus, Bovine Virus Diarrhea Type 2, Modified Live Virus. Administration routes: Unknown, Subcutaneous, Intramuscular.

By species: Cattle (87 reports). By breed: Cattle (other) (55), Aberdeen Angus (15), Crossbred Bovine/Cattle (7).

Leading clinical signs: Death (76), Lack of efficacy - NOS (35), Lack of efficacy (bacteria) - NOS (16), Lack of efficacy (virus) - NOS (8). Outcome, 150 coded reports: Died leads at 52.0%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.