Drug profile

The FDA adverse-event record for Bovine Parainfluenza 3 Virus, Modified Live Virus + Bovine Respiratory Syncytial Virus, Modified Live Virus + Bovine Rhinotracheitis Virus, Modified Live Virus + Bovine Virus Diarrhea Type 1, Modified Live Virus + Bovine Virus Diarrhea Type 2, Modified Live Virus + Mannheimia Haemolytica Toxoid

202 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Bovine Parainfluenza 3 Virus, Modified Live Virus + Bovine Respiratory Syncytial Virus, Modified Live Virus + Bovine Rhinotracheitis Virus, Modified Live Virus + Bovine Virus Diarrhea Type 1, Modified Live Virus + Bovine Virus Diarrhea Type 2, Modified Live Virus + Mannheimia Haemolytica Toxoid. See the species affected, top reactions, and outcomes below.

202
adverse-event reports
83.7%
death-coded share
Cattle
most-reported species
158
Death - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
202
Total Reports
169
Deaths Reported
83.7%
Death Rate

Active Ingredients

Bovine Parainfluenza 3 Virus, Modified Live VirusBovine Respiratory Syncytial Virus, Modified Live VirusBovine Rhinotracheitis Virus, Modified Live VirusBovine Virus Diarrhea Type 1, Modified Live VirusBovine Virus Diarrhea Type 2, Modified Live VirusMannheimia Haemolytica Toxoid

Administration Routes

UnknownSubcutaneousIntramuscularOther

Species Affected

Cattle 201
Human 1

Most Affected Breeds

Cattle (other) 122
Aberdeen Angus 31
Cattle (unknown) 25
Crossbred Bovine/Cattle 12
Charolais 3
Holstein-Friesian also known as Holstein 2
Brangus 2
Unknown 2
Simmental 1
Piedmont 1

Most Reported Reactions

Death 158
Lack of efficacy - NOS 101
Lack of efficacy (bacteria) - NOS 33
Necropsy performed 17
Death by euthanasia 15
Lack of efficacy (virus) - NOS 15
CULTURE/TITER DATA ABNORMAL 8
Respiratory signs 7
Lack of efficacy (bacteria NOS) 7
Depression 6
Anorexia 5
Other abnormal test result NOS 5

Outcome Breakdown

Died
165 (48.5%)
Outcome Unknown
74 (21.8%)
Recovered/Normal
43 (12.6%)
Ongoing
40 (11.8%)
Euthanized
12 (3.5%)
Recovered with Sequela
6 (1.8%)

Bovine Parainfluenza 3 Virus, Modified Live Virus + Bovine Respiratory Syncytial Virus, Modified Live Virus + Bovine Rhinotracheitis Virus, Modified Live Virus + Bovine Virus Diarrhea Type 1, Modified Live Virus + Bovine Virus Diarrhea Type 2, Modified Live Virus + Mannheimia Haemolytica Toxoid Adverse Event Insights

202 reports name Bovine Parainfluenza 3 Virus, Modified Live Virus + Bovine Respiratory Syncytial Virus, Modified Live Virus + Bovine Rhinotracheitis Virus, Modified Live Virus + Bovine Virus Diarrhea Type 1, Modified Live Virus + Bovine Virus Diarrhea Type 2, Modified Live Virus + Mannheimia Haemolytica Toxoid; 169 recorded a death outcome (83.7% of reported events, not a population-level mortality rate). Active ingredients: Bovine Parainfluenza 3 Virus, Modified Live Virus, Bovine Respiratory Syncytial Virus, Modified Live Virus, Bovine Rhinotracheitis Virus, Modified Live Virus, Bovine Virus Diarrhea Type 1, Modified Live Virus, Bovine Virus Diarrhea Type 2, Modified Live Virus. Administration routes: Unknown, Subcutaneous, Intramuscular, Other.

By species: Cattle (201 reports), Human (1 reports). By breed: Cattle (other) (122), Aberdeen Angus (31), Cattle (unknown) (25).

Leading clinical signs: Death (158), Lack of efficacy - NOS (101), Lack of efficacy (bacteria) - NOS (33), Necropsy performed (17). Outcome, 340 coded reports: Died leads at 48.5%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.