Drug profile

The FDA adverse-event record for Bovine Parainfluenza 3 Virus, Killed Virus + Bovine Respiratory Syncytial Virus, Killed Virus + Bovine Rhinotracheitis Virus, Killed Virus + Bovine Virus Diarrhea Type 1, Killed Virus + Bovine Virus Diarrhea Type 2, Killed Virus + Leptospira Canicola Bacterin + Leptospira Grippotyphosa Bacterin + Leptospira Hardjo Bacterin + Leptospira Icterohaemorrhagiae Bacterin + Leptospira Pomona Bacterin

24 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Bovine Parainfluenza 3 Virus, Killed Virus + Bovine Respiratory Syncytial Virus, Killed Virus + Bovine Rhinotracheitis Virus, Killed Virus + Bovine Virus Diarrhea Type 1, Killed Virus + Bovine Virus Diarrhea Type 2, Killed Virus + Leptospira Canicola Bacterin + Leptospira Grippotyphosa Bacterin + Leptospira Hardjo Bacterin + Leptospira Icterohaemorrhagiae Bacterin + Leptospira Pomona Bacterin. See the species affected, top reactions, and outcomes below.

24
adverse-event reports
41.7%
death-coded share
Cattle
most-reported species
9
Lack of efficacy - NOS - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
24
Total Reports
10
Deaths Reported
41.7%
Death Rate

Active Ingredients

Bovine Parainfluenza 3 Virus, Killed VirusBovine Respiratory Syncytial Virus, Killed VirusBovine Rhinotracheitis Virus, Killed VirusBovine Virus Diarrhea Type 1, Killed VirusBovine Virus Diarrhea Type 2, Killed VirusLeptospira Canicola BacterinLeptospira Grippotyphosa BacterinLeptospira Hardjo BacterinLeptospira Icterohaemorrhagiae BacterinLeptospira Pomona Bacterin

Administration Routes

UnknownSubcutaneous

Species Affected

Cattle 24

Most Affected Breeds

Cattle (other) 13
Aberdeen Angus 5
Holstein-Friesian also known as Holstein 2
Cattle (unknown) 2
Crossbred Bovine/Cattle 1
Brangus 1

Most Reported Reactions

Lack of efficacy - NOS 9
Death 9
Lack of efficacy (bacteria) - NOS 3
Abortion 2
Injection site lump 2
Lack of efficacy (virus) - NOS 2
Injection site infection 1
Recumbency 1
Injection site inflammation 1
Injection site stiffness 1
Unrelated death 1
Blindness 1

Outcome Breakdown

Outcome Unknown
10 (33.3%)
Died
10 (33.3%)
Recovered/Normal
8 (26.7%)
Ongoing
2 (6.7%)

Bovine Parainfluenza 3 Virus, Killed Virus + Bovine Respiratory Syncytial Virus, Killed Virus + Bovine Rhinotracheitis Virus, Killed Virus + Bovine Virus Diarrhea Type 1, Killed Virus + Bovine Virus Diarrhea Type 2, Killed Virus + Leptospira Canicola Bacterin + Leptospira Grippotyphosa Bacterin + Leptospira Hardjo Bacterin + Leptospira Icterohaemorrhagiae Bacterin + Leptospira Pomona Bacterin Adverse Event Insights

24 reports name Bovine Parainfluenza 3 Virus, Killed Virus + Bovine Respiratory Syncytial Virus, Killed Virus + Bovine Rhinotracheitis Virus, Killed Virus + Bovine Virus Diarrhea Type 1, Killed Virus + Bovine Virus Diarrhea Type 2, Killed Virus + Leptospira Canicola Bacterin + Leptospira Grippotyphosa Bacterin + Leptospira Hardjo Bacterin + Leptospira Icterohaemorrhagiae Bacterin + Leptospira Pomona Bacterin; 10 recorded a death outcome (41.7% of reported events, not a population-level mortality rate). Active ingredients: Bovine Parainfluenza 3 Virus, Killed Virus, Bovine Respiratory Syncytial Virus, Killed Virus, Bovine Rhinotracheitis Virus, Killed Virus, Bovine Virus Diarrhea Type 1, Killed Virus, Bovine Virus Diarrhea Type 2, Killed Virus. Administration routes: Unknown, Subcutaneous.

By species: Cattle (24 reports). By breed: Cattle (other) (13), Aberdeen Angus (5), Holstein-Friesian also known as Holstein (2).

Leading clinical signs: Lack of efficacy - NOS (9), Death (9), Lack of efficacy (bacteria) - NOS (3), Abortion (2). Outcome, 30 coded reports: Outcome Unknown leads at 33.3%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.