Drug profile

The FDA adverse-event record for Bovine Parainfluenza 3, Pi3 Ebk-1/Ebht-1 Strain Al-Im;Bovine Respiratory Syncyti

112 FDA reports name Bovine Parainfluenza 3, Pi3 Ebk-1/Ebht-1 Strain Al-Im;Bovine Respiratory Syncyti, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#734 of 2,679
by report volume (all drugs)
112
adverse-event reports
92.9%
death-coded share
Cattle
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Bovine Parainfluenza 3, Pi3 Ebk-1/Ebht-1 Strain Al-Im;Bovine Respiratory Syncyti ranks #734 of 2679 by total reports (112) and #2 of 1130 by death-coded share (92.9%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#734
This drug, reports of 2679
#2
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Bovine Parainfluenza 3, Pi3 Ebk-1/Ebht-1 Strain Al-Im;Bovine Respiratory Syncyti has 112 reports now versus 100 in that prior snapshot: 12 more (12.0%).

Report change
+12
Death-coded reports
+12
Death-coded share
+0.9 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Bovine Parainfluenza 3, Pi3 Ebk-1/Ebht-1 Strain Al-Im;Bovine Respiratory Syncyti changes

Signature read: Bovine Parainfluenza 3, Pi3 Ebk-1/Ebht-1 Strain Al-Im;Bovine Respiratory Syncyti's 92.9% death-coded share is among the highest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
112
Total Reports
104
Deaths Reported
92.9%
Death-coded share of reports

Active Ingredients

Bovine Parainfluenza 3, Pi3 Ebk-1/Ebht-1 Strain Al-Im;Bovine Respiratory Syncyti

Administration Routes

SubcutaneousIntramuscularUnknownOphthalmic

Species Affected

Cattle 112

Most Affected Breeds

Mixed (Cattle) 84
Cattle (other) 10
Aberdeen Angus 9
Crossbred Bovine/Cattle 2
Limousin 2
Red Angus 2
Jersey 1
Holstein-Friesian also known as Holstein 1
Brahman 1

Most Reported Reactions

Death 96
Lack of efficacy - NOS 81
Necropsy performed 66
Lack of efficacy (bacteria) - Mannheimia haemolytica 14
Intentional misuse 12
Lack of efficacy (bacteria) - Histophilus somni 12
Lack of efficacy (mycoplasma) - NOS 7
Suppurative (broncho) pneumonia/pleuropneumonia 6
Pneumonia 5
Lack of efficacy (virus) - bovine viral diarrhoea virus 5
Anaphylaxis 4
Fibrinous (broncho) pneumonia/fibrinous pleuropneumonia 4

Outcome Breakdown

Died
104 (51.2%)
Outcome Unknown
47 (23.2%)
Ongoing
30 (14.8%)
Recovered/Normal
15 (7.4%)
Euthanized
4 (2.0%)
Recovered with Sequela
3 (1.5%)

Bovine Parainfluenza 3, Pi3 Ebk-1/Ebht-1 Strain Al-Im;Bovine Respiratory Syncyti: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Bovine Parainfluenza 3, Pi3 Ebk-1/Ebht-1 Strain Al-Im;Bovine Respiratory Syncyti, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

  • Compare Bovine Parainfluenza 3, Pi3 Ebk-1/Ebht-1 Strain Al-Im;Bovine Respiratory Syncyti's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Bovine Parainfluenza 3, Pi3 Ebk-1/Ebht-1 Strain Al-Im;Bovine Respiratory Syncyti (#734 of 2,679 by report volume); death-coded 92.9%. PlainBreed drug row · death-coded share stamp 92.9% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →