Drug profile

The FDA adverse-event record for Bordetella

511 FDA reports name Bordetella, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#300 of 2,679
by report volume (all drugs)
511
adverse-event reports
8.4%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Bordetella ranks #300 of 2679 by total reports (511) and #624 of 1130 by death-coded share (8.4%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#300
This drug, reports of 2679
#624
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Bordetella has 511 reports now versus 494 in that prior snapshot: 17 more (3.4%).

Report change
+17
Death-coded reports
+4
Death-coded share
+0.5 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Bordetella changes

Signature read: 511 reports place Bordetella in the upper third of FDA AER volume (#300 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
511
Total Reports
43
Deaths Reported
8.4%
Death-coded share of reports

Active Ingredients

Bordetella

Administration Routes

UnknownNasalOralSubcutaneousParenteralIntralesional

Species Affected

Dog 507
Cat 3
Goat 1

Most Affected Breeds

Retriever - Labrador 43
Terrier - Bull - American Pit 36
Crossbred Canine/dog 35
Chihuahua 27
Retriever - Golden 25
Terrier - Yorkshire 23
Shepherd Dog - German 18
Boxer (German Boxer) 18
Shih Tzu 16
Terrier (unspecified) 14

Most Reported Reactions

Vomiting 186
Lethargy (see also Central nervous system depression in 'Neurological') 77
Anaphylaxis 76
Diarrhoea 60
Facial swelling (see also 'Skin') 57
Hives (see also 'Skin') 56
Lethargy (see also Central nervous system depression in Neurological) 47
Pale mucous membrane 40
Seizure NOS 33
Emesis (multiple) 30
Not eating 29
Emesis 28

Outcome Breakdown

Ongoing
209 (40.9%)
Recovered/Normal
201 (39.3%)
Outcome Unknown
58 (11.4%)
Died
23 (4.5%)
Euthanized
20 (3.9%)

Bordetella: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Bordetella, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Bordetella (#300 of 2,679 by report volume); death-coded 8.4%. PlainBreed drug row · report volume stamp 511 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →