Drug profile

The FDA adverse-event record for Bone And Joint Support

65 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Bone And Joint Support. Species, reactions, and outcomes follow.

#970 of 2,679
by report volume (all drugs)
65
adverse-event reports
7.7%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Bone And Joint Support ranks #970 of 2679 by total reports (65) and #658 of 1130 by death-coded share (7.7%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#970
This drug, reports of 2679
#658
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Bone And Joint Support has 65 reports now versus 65 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Bone And Joint Support changes

Signature read: report volume at 65 is the most distinctive stamp on Bone And Joint Support's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
65
Total Reports
5
Deaths Reported
7.7%
Death-coded share of reports

Active Ingredients

Bone And Joint Support

Administration Routes

OralUnknownIntramuscular

Species Affected

Dog 60
Cat 4
Human 1

Most Affected Breeds

Retriever - Labrador 12
Retriever - Golden 4
Boxer (German Boxer) 3
Shepherd Dog - Australian 3
Shepherd Dog - German 3
Domestic Shorthair 3
Crossbred Canine/dog 2
Chihuahua 2
Collie - Border 2
Spitz - German Pomeranian 2

Most Reported Reactions

Vomiting 16
Diarrhoea 7
Other abnormal test result NOS 6
Emesis 5
Death by euthanasia 5
Anaemia NOS 5
Lack of efficacy - NOS 4
Abnormal radiograph finding 4
Elevated blood urea nitrogen (BUN) 4
Seizure NOS 3
Lethargy (see also Central nervous system depression in 'Neurological') 3
Bone and joint disorder NOS 3

Outcome Breakdown

Outcome Unknown
25 (38.5%)
Ongoing
19 (29.2%)
Recovered/Normal
15 (23.1%)
Euthanized
5 (7.7%)
Recovered with Sequela
1 (1.5%)

Bone And Joint Support Adverse Event Insights

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Nationwide drugs with similar profiles

Two openFDA-derived peer sets for Bone And Joint Support, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar report volume

Nearest other drugs by FDA report count (65 here).

Similar death-coded share

Nearest other drugs by death-coded share (7.7% here), distinct from the volume row.

What to do with this drug

  • Compare Bone And Joint Support's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Bone And Joint Support (#970 of 2,679 by report volume); death-coded 7.7%. PlainBreed drug row · report volume stamp 65 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →