Drug profile

The FDA adverse-event record for Bismuth Subnitrate 60% Intramammary

37 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Bismuth Subnitrate 60% Intramammary. See the species affected, top reactions, and outcomes below.

37
adverse-event reports
78.4%
death-coded share
Cattle
most-reported species
27
Death - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
37
Total Reports
29
Deaths Reported
78.4%
Death Rate

Active Ingredients

Bismuth Subnitrate 60% Intramammary

Administration Routes

IntramammaryUnknownOral

Species Affected

Cattle 37

Most Affected Breeds

Holstein-Friesian also known as Holstein 18
Cattle (other) 12
Cattle (unknown) 5
Unknown 1
Jersey 1

Most Reported Reactions

Death 27
Lack of efficacy (bacteria) - NOS 17
Acute mastitis 8
CULTURE/TITER DATA ABNORMAL 5
Mastitis NOS 5
NT - Abnormal necropsy finding NOS 4
Necropsy performed 4
Lack of efficacy (bacteria) - E.coli 3
INEFFECTIVE, ANTIBIOTIC 2
Septicaemia 2
Diarrhoea 2
Fever 2

Outcome Breakdown

Died
27 (50.9%)
Outcome Unknown
12 (22.6%)
Recovered/Normal
11 (20.8%)
Euthanized
2 (3.8%)
Ongoing
1 (1.9%)

Bismuth Subnitrate 60% Intramammary Adverse Event Insights

37 reports name Bismuth Subnitrate 60% Intramammary; 29 recorded a death outcome (78.4% of reported events, not a population-level mortality rate). Active ingredient: Bismuth Subnitrate 60% Intramammary. Administration routes: Intramammary, Unknown, Oral.

By species: Cattle (37 reports). By breed: Holstein-Friesian also known as Holstein (18), Cattle (other) (12), Cattle (unknown) (5).

Leading clinical signs: Death (27), Lack of efficacy (bacteria) - NOS (17), Acute mastitis (8), CULTURE/TITER DATA ABNORMAL (5). Outcome, 53 coded reports: Died leads at 50.9%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.