Drug profile

The FDA adverse-event record for Bismuth Subnitrate

36 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Bismuth Subnitrate. Species, reactions, and outcomes follow.

#1312 of 2,679
by report volume (all drugs)
36
adverse-event reports
38.9%
death-coded share
Cattle
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Bismuth Subnitrate ranks #1311 of 2679 by total reports (36). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1311
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Bismuth Subnitrate has 36 reports now versus 36 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Bismuth Subnitrate changes

Signature read: Bismuth Subnitrate's 38.9% death-coded share is among the highest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
36
Total Reports
14
Deaths Reported
38.9%
Death-coded share of reports

Active Ingredients

Bismuth Subnitrate

Administration Routes

UnknownIntramammary

Species Affected

Cattle 30
Unknown 6

Most Affected Breeds

Cattle (other) 16
Jersey 6
Unknown 6
Holstein-Friesian also known as Holstein 6
Crossbred Bovine/Cattle 1
Mixed (Cattle) 1

Most Reported Reactions

Lack of efficacy (bacteria) - NOS 16
Death 9
Lack of efficacy - NOS 7
Product Defect, General 3
Abortion 3
Device Defective NOS 3
Diarrhoea 2
CULTURE/TITER DATA ABNORMAL 2
Downer animal 2
Mastitis NOS 2
Digestive tract disorder NOS 2
Urticaria 1

Outcome Breakdown

Outcome Unknown
18 (43.9%)
Died
12 (29.3%)
Recovered/Normal
4 (9.8%)
Ongoing
4 (9.8%)
Euthanized
2 (4.9%)
Recovered with Sequela
1 (2.4%)

Bismuth Subnitrate: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Bismuth Subnitrate (#1312 of 2,679 by report volume); death-coded 38.9%. PlainBreed drug row · death-coded share stamp 38.9% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →