Drug profile

The FDA adverse-event record for B12 Injection

20 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference B12 Injection. See the species affected, top reactions, and outcomes below.

20
adverse-event reports
15.0%
death-coded share
Dog
most-reported species
6
Diarrhoea - top reaction
Verify with FDA CVM →
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
20
Total Reports
3
Deaths Reported
15.0%
Death Rate

Active Ingredients

B12 Injection

Administration Routes

UnknownSubcutaneousIntravenous

Species Affected

Dog 13
Cat 7

Most Affected Breeds

Domestic Shorthair 3
Cat (unknown) 2
Terrier (unspecified) 2
Poodle (unspecified) 2
Terrier - Yorkshire 1
Siamese 1
Retriever - Golden 1
Crossbred Canine/dog 1
Greyhound 1
Retriever - Labrador 1

Most Reported Reactions

Diarrhoea 6
Behavioural disorder NOS 5
Other abnormal test result NOS 5
Abnormal radiograph finding 4
Vomiting 4
Bilirubinuria 4
Monocytosis 4
Heavy breathing 4
Limb weakness 4
Tachycardia 3
Anorexia 3
Ataxia 3

Outcome Breakdown

Ongoing
9 (42.9%)
Recovered/Normal
5 (23.8%)
Outcome Unknown
3 (14.3%)
Died
2 (9.5%)
Euthanized
2 (9.5%)

B12 Injection Adverse Event Insights

20 reports name B12 Injection; 3 recorded a death outcome (15.0% of reported events, not a population-level mortality rate). Active ingredient: B12 Injection. Administration routes: Unknown, Subcutaneous, Intravenous.

By species: Dog (13 reports), Cat (7 reports). By breed: Domestic Shorthair (3), Cat (unknown) (2), Terrier (unspecified) (2).

Leading clinical signs: Diarrhoea (6), Behavioural disorder NOS (5), Other abnormal test result NOS (5), Abnormal radiograph finding (4). Outcome, 21 coded reports: Ongoing leads at 42.9%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.