Drug profile

The FDA adverse-event record for Ampicillin Trihydrate

362 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Ampicillin Trihydrate. See the species affected, top reactions, and outcomes below.

362
adverse-event reports
29.0%
death-coded share
Dog
most-reported species
68
Death - top reaction
Verify with FDA CVM →
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
362
Total Reports
105
Deaths Reported
29.0%
Death Rate

Active Ingredients

Ampicillin Trihydrate

Administration Routes

UnknownIntramuscularSubcutaneousIntravenousParenteralRespiratory (Inhalation)TopicalOral

Species Affected

Dog 125
Cattle 124
Unknown 73
Cat 33
Horse 4
Human 2
Sheep 1

Most Affected Breeds

Unknown 75
Holstein-Friesian also known as Holstein 73
Cattle (other) 24
Retriever - Labrador 15
Domestic Shorthair 15
Dog (unknown) 14
Cattle (unknown) 10
Domestic (unspecified) 9
Pit Bull 8
Terrier - Yorkshire 7

Most Reported Reactions

Death 68
Death by euthanasia 28
Vomiting 22
Anorexia 22
Injection site swelling 22
Lethargy (see also Central nervous system depression in 'Neurological') 19
Diarrhoea 18
Residues in meat/offal 18
Other abnormal test result NOS 17
Dehydration 15
Anaphylaxis 15
Anaemia NOS 14

Outcome Breakdown

Recovered/Normal
93 (35.1%)
Died
73 (27.5%)
Outcome Unknown
45 (17.0%)
Euthanized
33 (12.5%)
Ongoing
12 (4.5%)
Recovered with Sequela
9 (3.4%)

Ampicillin Trihydrate Adverse Event Insights

362 reports name Ampicillin Trihydrate; 105 recorded a death outcome (29.0% of reported events, not a population-level mortality rate). Active ingredient: Ampicillin Trihydrate. Administration routes: Unknown, Intramuscular, Subcutaneous, Intravenous.

By species: Dog (125 reports), Cattle (124 reports), Unknown (73 reports). By breed: Unknown (75), Holstein-Friesian also known as Holstein (73), Cattle (other) (24).

Leading clinical signs: Death (68), Death by euthanasia (28), Vomiting (22), Anorexia (22). Outcome, 265 coded reports: Recovered/Normal leads at 35.1%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.