Drug profile

The FDA adverse-event record for Amoxicillin Trihydrate/Clavulanic Acid

86 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Amoxicillin Trihydrate/Clavulanic Acid. See the species affected, top reactions, and outcomes below.

86
adverse-event reports
11.6%
death-coded share
Dog
most-reported species
19
Lethargy (see also Central nervous system depression in 'Neurological') - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
86
Total Reports
10
Deaths Reported
11.6%
Death Rate

Active Ingredients

Amoxicillin Trihydrate/Clavulanic Acid

Administration Routes

OralUnknown

Species Affected

Dog 52
Cat 34

Most Affected Breeds

Domestic Shorthair 20
Domestic Longhair 6
Retriever - Labrador 6
Crossbred Canine/dog 5
Shepherd Dog - Australian 4
Terrier - Yorkshire 3
Terrier - Jack Russell 2
Dachshund - Miniature 2
Retriever - Golden 2
Maine Coon 2

Most Reported Reactions

Lethargy (see also Central nervous system depression in 'Neurological') 19
Vomiting 16
Other abnormal test result NOS 15
Diarrhoea 12
Anorexia 10
Ataxia 10
Behavioural disorder NOS 10
Erythema (for urticaria see Immune SOC) 8
Death by euthanasia 8
Emesis (multiple) 8
Application site alopecia 7
Polydipsia 7

Outcome Breakdown

Outcome Unknown
55 (64.7%)
Recovered/Normal
17 (20.0%)
Euthanized
5 (5.9%)
Died
5 (5.9%)
Ongoing
3 (3.5%)

Amoxicillin Trihydrate/Clavulanic Acid Adverse Event Insights

86 reports name Amoxicillin Trihydrate/Clavulanic Acid; 10 recorded a death outcome (11.6% of reported events, not a population-level mortality rate). Active ingredient: Amoxicillin Trihydrate/Clavulanic Acid. Administration routes: Oral, Unknown.

By species: Dog (52 reports), Cat (34 reports). By breed: Domestic Shorthair (20), Domestic Longhair (6), Retriever - Labrador (6).

Leading clinical signs: Lethargy (see also Central nervous system depression in 'Neurological') (19), Vomiting (16), Other abnormal test result NOS (15), Diarrhoea (12). Outcome, 85 coded reports: Outcome Unknown leads at 64.7%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.