Drug profile

The FDA adverse-event record for Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate)

857 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate). See the species affected, top reactions, and outcomes below.

857
adverse-event reports
11.7%
death-coded share
Dog
most-reported species
295
Color, Abnormal - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
857
Total Reports
100
Deaths Reported
11.7%
Death Rate

Active Ingredients

Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate)

Administration Routes

OralUnknownTopicalOtherOphthalmic

Species Affected

Dog 363
Unknown 344
Cat 144
Human 4
Other Birds 1
Other Rodents 1

Most Affected Breeds

Unknown 348
Domestic Shorthair 77
Retriever - Labrador 25
Terrier - Yorkshire 21
Cat (unknown) 20
Chihuahua 19
Dog (unknown) 19
Shih Tzu 19
Boxer (German Boxer) 17
Domestic Longhair 16

Most Reported Reactions

Color, Abnormal 295
Suspension, Abnormal 246
Lethargy (see also Central nervous system depression in 'Neurological') 127
Vomiting 106
Lack of efficacy - NOS 104
Other abnormal test result NOS 102
Lack of efficacy (bacteria) - NOS 86
Anorexia 80
Diarrhoea 62
Death by euthanasia 50
Emesis 49
Death 48

Outcome Breakdown

Ongoing
254 (49.3%)
Outcome Unknown
81 (15.7%)
Recovered/Normal
78 (15.1%)
Died
53 (10.3%)
Euthanized
48 (9.3%)
Recovered with Sequela
1 (0.2%)

Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate) Adverse Event Insights

857 reports name Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate); 100 recorded a death outcome (11.7% of reported events, not a population-level mortality rate). Active ingredient: Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate). Administration routes: Oral, Unknown, Topical, Other.

By species: Dog (363 reports), Unknown (344 reports), Cat (144 reports). By breed: Unknown (348), Domestic Shorthair (77), Retriever - Labrador (25).

Leading clinical signs: Color, Abnormal (295), Suspension, Abnormal (246), Lethargy (see also Central nervous system depression in 'Neurological') (127), Vomiting (106). Outcome, 515 coded reports: Ongoing leads at 49.3%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.