Drug profile

The FDA adverse-event record for Amoxicillin + Potassium Clavulanate

33 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Amoxicillin + Potassium Clavulanate. See the species affected, top reactions, and outcomes below.

33
adverse-event reports
12.1%
death-coded share
Dog
most-reported species
6
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
33
Total Reports
4
Deaths Reported
12.1%
Death Rate

Active Ingredients

Amoxicillin + Potassium Clavulanate

Administration Routes

UnknownOral

Species Affected

Dog 21
Cat 12

Most Affected Breeds

Domestic Shorthair 9
Retriever - Labrador 4
Crossbred Canine/dog 3
Chihuahua 2
Japanese Chin (Spaniel) 2
Cat (unknown) 2
Mountain Dog - Bernese 2
Bulldog - French 2
Pug 1
Great Pyrenees 1

Most Reported Reactions

Vomiting 6
Diarrhoea 6
Lethargy (see also Central nervous system depression in Neurological) 6
Other abnormal test result NOS 6
Dehydration 5
Elevated alanine aminotransferase (ALT) 5
Ataxia 4
Lack of efficacy - NOS 4
Decreased appetite 4
Local swelling (not application site) 3
Not eating 3
Decreased haematocrit 3

Outcome Breakdown

Ongoing
16 (48.5%)
Outcome Unknown
7 (21.2%)
Recovered/Normal
6 (18.2%)
Died
2 (6.1%)
Euthanized
2 (6.1%)

Amoxicillin + Potassium Clavulanate Adverse Event Insights

33 reports name Amoxicillin + Potassium Clavulanate; 4 recorded a death outcome (12.1% of reported events, not a population-level mortality rate). Active ingredient: Amoxicillin + Potassium Clavulanate. Administration routes: Unknown, Oral.

By species: Dog (21 reports), Cat (12 reports). By breed: Domestic Shorthair (9), Retriever - Labrador (4), Crossbred Canine/dog (3).

Leading clinical signs: Vomiting (6), Diarrhoea (6), Lethargy (see also Central nervous system depression in Neurological) (6), Other abnormal test result NOS (6). Outcome, 33 coded reports: Ongoing leads at 48.5%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.