Drug profile

The FDA adverse-event record for Amoxicillin As Trihydrate; Clavulanate Potassium ( K-Clavulanate)

271 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Amoxicillin As Trihydrate; Clavulanate Potassium ( K-Clavulanate). See the species affected, top reactions, and outcomes below.

271
adverse-event reports
7.0%
death-coded share
Unknown
most-reported species
134
Color, Abnormal - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
271
Total Reports
19
Deaths Reported
7.0%
Death Rate

Active Ingredients

Amoxicillin As Trihydrate; Clavulanate Potassium ( K-Clavulanate)

Administration Routes

UnknownOralOphthalmic

Species Affected

Unknown 141
Dog 91
Cat 39

Most Affected Breeds

Unknown 141
Domestic Shorthair 19
Retriever - Labrador 14
Beagle 7
Terrier - Yorkshire 7
Cat (unknown) 6
Bichon Frise 5
Chihuahua 5
Siberian Husky 3
Persian 3

Most Reported Reactions

Color, Abnormal 134
Suspension, Abnormal 85
Uncoded sign 53
Lack of efficacy (bacteria) - NOS 34
Lethargy (see also Central nervous system depression in 'Neurological') 29
Vomiting 24
Anorexia 22
Other abnormal test result NOS 20
Diarrhoea 17
Lack of efficacy - NOS 12
Anaemia NOS 11
Death by euthanasia 10

Outcome Breakdown

Ongoing
69 (52.7%)
Recovered/Normal
24 (18.3%)
Outcome Unknown
19 (14.5%)
Euthanized
11 (8.4%)
Died
8 (6.1%)

Amoxicillin As Trihydrate; Clavulanate Potassium ( K-Clavulanate) Adverse Event Insights

271 reports name Amoxicillin As Trihydrate; Clavulanate Potassium ( K-Clavulanate); 19 recorded a death outcome (7.0% of reported events, not a population-level mortality rate). Active ingredient: Amoxicillin As Trihydrate; Clavulanate Potassium ( K-Clavulanate). Administration routes: Unknown, Oral, Ophthalmic.

By species: Unknown (141 reports), Dog (91 reports), Cat (39 reports). By breed: Unknown (141), Domestic Shorthair (19), Retriever - Labrador (14).

Leading clinical signs: Color, Abnormal (134), Suspension, Abnormal (85), Uncoded sign (53), Lack of efficacy (bacteria) - NOS (34). Outcome, 131 coded reports: Ongoing leads at 52.7%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.