Drug profile

The FDA adverse-event record for Amoxicillin (As Trihydrate); Clavulanate Potassium ( K-Clavulanate)

1,076 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Amoxicillin (As Trihydrate); Clavulanate Potassium ( K-Clavulanate). See the species affected, top reactions, and outcomes below.

1,076
adverse-event reports
12.1%
death-coded share
Dog
most-reported species
305
Color, Abnormal - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
1,076
Total Reports
130
Deaths Reported
12.1%
Death Rate

Active Ingredients

Amoxicillin (As Trihydrate); Clavulanate Potassium ( K-Clavulanate)

Administration Routes

OralUnknownSubcutaneousOphthalmicAuricular (Otic)Other

Species Affected

Dog 489
Unknown 395
Cat 191
Other 1

Most Affected Breeds

Unknown 396
Domestic Shorthair 112
Retriever - Labrador 47
Chihuahua 40
Shih Tzu 30
Terrier - Yorkshire 27
Domestic Longhair 24
Maltese 21
Retriever - Golden 19
Pug 19

Most Reported Reactions

Color, Abnormal 305
No sign 208
Vomiting 189
Lethargy (see also Central nervous system depression in 'Neurological') 153
Anorexia 113
Other abnormal test result NOS 86
Lack of efficacy (bacteria) - NOS 80
Uncoded sign 77
Diarrhoea 68
Death 63
Death by euthanasia 60
Elevated serum alkaline phosphatase (SAP) 58

Outcome Breakdown

Ongoing
352 (51.6%)
Recovered/Normal
107 (15.7%)
Outcome Unknown
93 (13.6%)
Died
69 (10.1%)
Euthanized
61 (8.9%)

Amoxicillin (As Trihydrate); Clavulanate Potassium ( K-Clavulanate) Adverse Event Insights

1,076 reports name Amoxicillin (As Trihydrate); Clavulanate Potassium ( K-Clavulanate); 130 recorded a death outcome (12.1% of reported events, not a population-level mortality rate). Active ingredient: Amoxicillin (As Trihydrate); Clavulanate Potassium ( K-Clavulanate). Administration routes: Oral, Unknown, Subcutaneous, Ophthalmic.

By species: Dog (489 reports), Unknown (395 reports), Cat (191 reports). By breed: Unknown (396), Domestic Shorthair (112), Retriever - Labrador (47).

Leading clinical signs: Color, Abnormal (305), No sign (208), Vomiting (189), Lethargy (see also Central nervous system depression in 'Neurological') (153). Outcome, 682 coded reports: Ongoing leads at 51.6%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.