Drug profile

The FDA adverse-event record for Amoxicillin Anhydrous + Clavulanic Acid

38 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Amoxicillin Anhydrous + Clavulanic Acid. Species, reactions, and outcomes follow.

#1283 of 2,679
by report volume (all drugs)
38
adverse-event reports
15.8%
death-coded share
Unknown
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Amoxicillin Anhydrous + Clavulanic Acid ranks #1283 of 2679 by total reports (38). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1283
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Amoxicillin Anhydrous + Clavulanic Acid has 38 reports now versus 38 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Amoxicillin Anhydrous + Clavulanic Acid changes

Signature read: death-coded share at 15.8% is the most distinctive stamp on Amoxicillin Anhydrous + Clavulanic Acid's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
38
Total Reports
6
Deaths Reported
15.8%
Death-coded share of reports

Active Ingredients

Amoxicillin AnhydrousClavulanic Acid

Administration Routes

UnknownOral

Species Affected

Unknown 20
Dog 15
Cat 3

Most Affected Breeds

Unknown 20
Retriever - Golden 3
Dachshund (unspecified) 2
Crossbred Canine/dog 2
Pointing Dog - German Short-haired 1
Domestic Longhair 1
Boxer (German Boxer) 1
Bulldog 1
Griffon - French Wire-haired Pointing 1
Domestic Shorthair 1

Most Reported Reactions

Color, Abnormal 9
Death by euthanasia 6
Lethargy (see also Central nervous system depression in 'Neurological') 5
Vomiting 5
Suspension, Abnormal 4
Anaemia NOS 4
Diarrhoea 4
Abnormal ultrasound finding 4
Other abnormal test result NOS 4
Lot # and/or Expiration date incorrect 4
Contamination, Mold 4
Anorexia 3

Outcome Breakdown

Euthanized
5 (29.4%)
Recovered/Normal
4 (23.5%)
Outcome Unknown
3 (17.6%)
Ongoing
3 (17.6%)
Recovered with Sequela
1 (5.9%)
Died
1 (5.9%)

Amoxicillin Anhydrous + Clavulanic Acid Adverse Event Insights

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Amoxicillin Anhydrous + Clavulanic Acid (#1283 of 2,679 by report volume); death-coded 15.8%. PlainBreed drug row · death-coded share stamp 15.8% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →