Amitriptyline

176 adverse event reports submitted to the FDA

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.

176

Total Reports

Deaths Reported

570.0%

Death Rate

Active Ingredients

Amitriptyline

Administration Routes

OralUnknownTopicalTransdermalOther

Species Affected

Dog 120

Cat 51

Human 4

Unknown 1

Most Affected Breeds

Domestic Shorthair 40

Retriever - Labrador 11

Shih Tzu 8

Crossbred Canine/dog 6

Spaniel - King Charles Cavalier 6

Unknown 5

Retriever - Golden 5

Shepherd Dog - Australian 5

Domestic Mediumhair 4

Poodle (unspecified) 4

Most Reported Reactions

Vomiting 44

Lethargy (see also Central nervous system depression in 'Neurological') 27

Emesis 19

Diarrhoea 13

Lack of efficacy - NOS 11

Behavioural disorder NOS 11

Seizure NOS 11

Anorexia 10

Other abnormal test result NOS 10

Elevated alanine aminotransferase (ALT) 10

Pruritus 10

Elevated serum alkaline phosphatase (SAP) 9

Outcome Breakdown

Recovered/Normal

77 (44.3%)

Ongoing

47 (27.0%)

Outcome Unknown

32 (18.4%)

Recovered with Sequela

8 (4.6%)

Died

5 (2.9%)

Euthanized

5 (2.9%)

Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.